Hem-Onc - Antitumor Antibiotics Flashcards
Dactinomycin (actinomycin D): mech
Intercalates in DNA
Dactinomycin: uses
Wilms tumor, Ewing sarcoma, rhabdomyosarcoma.
Used for childhood tumors (“children ACT out”)
Dactinomycin: tox
Myelosuppression
Doxorubicin (Adriamycin): mech
Generate free radicals. Intercalate in DNA –> breaks in DNA –> decreased replication
Antitumor activity in tetracycline ring
Doxorubicin: uses
Solid tumors, leukemias, lymphomas
Doxorubicin: tox
Cardiotoxicity (dilated cardiomyopathy), myelosuppression, alopecia.
Toxic to tissues following extravasation.
Dexrazoxane (iron chelating agent) used to prevent cardiotoxicity
Drug used to prevent cardiotoxicity with doxorubicin/daunorubicin use:
Dexrazoxane (iron chelating agent)
Daunorubicin: mech
Generate free radicals.
Intercalates DNA –> breaks in DNA –> decreased replication
Daunorubicin: uses
Solid tumors, leukemias, lymphomas.
Daunorubicin: tox
Cardiotoxicity (dilated cardiomyopathy), myelosuppression, alopecia.
Toxic to tissues following extravasation.
Dexrazone (iron chelating agent), used to prevent cardiotoxicity
Bleomycin: mech
Induces free radical formation, which causes breaks in DNA strands
Bleomycin: uses
Testicular cancer, Hodgkin lymphoma
Bleomycin: uses
Testicular cancer, Hodgkin lymphoma
Bleomycin: tox
Pulmonary fibrosis, skin changes, mucositis.
Minimal myelosuppresion