Hem-Onc - Antitumor Antibiotics Flashcards

1
Q

Dactinomycin (actinomycin D): mech

A

Intercalates in DNA

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2
Q

Dactinomycin: uses

A

Wilms tumor, Ewing sarcoma, rhabdomyosarcoma.

Used for childhood tumors (“children ACT out”)

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3
Q

Dactinomycin: tox

A

Myelosuppression

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4
Q

Doxorubicin (Adriamycin): mech

A

Generate free radicals. Intercalate in DNA –> breaks in DNA –> decreased replication
Antitumor activity in tetracycline ring

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5
Q

Doxorubicin: uses

A

Solid tumors, leukemias, lymphomas

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6
Q

Doxorubicin: tox

A

Cardiotoxicity (dilated cardiomyopathy), myelosuppression, alopecia.
Toxic to tissues following extravasation.
Dexrazoxane (iron chelating agent) used to prevent cardiotoxicity

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7
Q

Drug used to prevent cardiotoxicity with doxorubicin/daunorubicin use:

A

Dexrazoxane (iron chelating agent)

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8
Q

Daunorubicin: mech

A

Generate free radicals.

Intercalates DNA –> breaks in DNA –> decreased replication

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9
Q

Daunorubicin: uses

A

Solid tumors, leukemias, lymphomas.

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10
Q

Daunorubicin: tox

A

Cardiotoxicity (dilated cardiomyopathy), myelosuppression, alopecia.
Toxic to tissues following extravasation.
Dexrazone (iron chelating agent), used to prevent cardiotoxicity

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11
Q

Bleomycin: mech

A

Induces free radical formation, which causes breaks in DNA strands

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12
Q

Bleomycin: uses

A

Testicular cancer, Hodgkin lymphoma

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13
Q

Bleomycin: uses

A

Testicular cancer, Hodgkin lymphoma

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14
Q

Bleomycin: tox

A

Pulmonary fibrosis, skin changes, mucositis.

Minimal myelosuppresion

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