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BT_anatomySTEP > hem onc > Flashcards

hem onc Flashcards

1
Q

what are these?

A

erythrocytes

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2
Q

life span of erythrocytes?

A

120 days

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3
Q

which cell has HCO3/Cl antiporter in membrane?

A

RBC - allows export of HCO3 and transport of CO2 to lungs

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4
Q

what are these? (arrows)

A

platelets

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5
Q

lifespan of platelets?

A

8-10 days

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6
Q

what is in dense granules? what cells have dense granules?

A

contents: ADP, Ca

in platelets

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7
Q

what is in alpha granules? what cells have alpha granules?

A

vWF, fibrinogen

in platelets

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8
Q

what are the vWF and fibrinogen receptors?

A

vWF: GP Ib

fibrinogen: GP IIb/IIIa

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9
Q

WBC differential from highest to lowest?

A

Neutrophils Like Making Everything Better

neutrophils

lymphocytes

monocytes

eosinophils

basophils

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10
Q

what kind of cell is this? (arrow)

A

neutrophil: multilobed nucleus

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11
Q

what is in specific granules? what cell has specific granules?

A

ALP, collagenase, lysozyme, lactoferrin

in neutrophils

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12
Q

what is in azurophilic granules? what cell has azurophilic granules?

A

proteinases, acid phosphatase, myeloperoxidase, beta-glucuronidase

in neutrophils

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13
Q

when do you see bandemia?

A

myeloid proliferation: bacterial infection, CML

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14
Q

what are neutrophil chemotactic agents?

A

C5a, IL8, LTB4, kallikrein, platelet-activating factor

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15
Q

what kind of cells are these? (arrows)

A

monocytes

large kidney shaped nucleus

frosted-glass cytoplasm

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16
Q

what kind of cell is this? (arrow)

A

macrophage

17
Q

where do macrophages come from?

A

monocytes; activated by IFN-gamma

18
Q

which cell has CD14 and what does it do?

A

macrophage

lipid A (LPS) binds CD14 –> septic shock

19
Q

what kinds of cells are these (short fat arrows)?

A

eosinophils (bilobate nucleus, eosinophilic granules)

20
Q

what do eosinophils produce?

A

histaminase

major basic protein (kills helminths)

21
Q

what are causes of eosinophila?

A

NAACP

neoplasia

asthma

allergic processes

chronic adrenal insufficiency

parasites

22
Q

what kinds of cells are these (long skinny arrows)?

A

basophils

basophilic granules

23
Q

what are in basophil granules?

A

heparain and histamine

leukotrienes synthesized on demand

24
Q

when do you see basophilia?

25
Q

what kind of cell is this (arrow)?

A

mast cell

basophilic granules (less basophilic than basophil)

26
Q

how do mast cells work?

A

bind Fc portion of IgE –> facilitate cross-linking with Ag binding

release histamine, heparin, eosinophil chemotactic factors

27
Q

what does cromolyn sodium do?

A

prevents mast cell degranulation - asthma ppx

28
Q

what kind of cell is this?

A

lymphocyte

clock face chromatin

abundant RER and well-developed Golgi

BT_anatomySTEP (10 decks)

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