Hefs Lectures - Lung

Question 1

small cell lung cancer vs NSLC

Answer 1

• small cell -> treat w/ chemo/radiation

- NSLC -> treat w/ surgical resection

Question 2

central producing lung cancers

Answer 2

1. small cell carcinoma
2. SCC

-see a “HONEYCOMB” lung lesion

Question 3

peripheral producing tumor

Answer 3

ADENOCARCINOMA

Question 4

Squamous Cell Carcinoma (SCC)

Answer 4

• central

- INTERCELLULAR bridges & KERATIN pearls

Question 5

small cell carcinoma

Answer 5

• central
• HIGH malignancy
• neurosecretory -> ACTH, ADH

-arise from neuroendocrine (Kulchitsky cells)

Question 6

DIFFUSE chromatin, SPARSE cytoplasm

Answer 6

OAT CELL carcinoma

-a variant of small cell carcinoma

Question 7

Adenocarcinoma

Answer 7

• PERIPHERAL
• MUCUS & GLANDS
• scarring
• markers -> TTF-1, Napsin A

Question 8

what type of lung cancer is UNDIFFERENTIATED & malignant?

Answer 8

Large cell carcinoma

• distractor
• many types of cancers

Question 9

PANCOAST tumor

Answer 9

• sympathetic chain -> HORNER syndrome
• brachial plexus

-can also have SVC syndrome

Question 10

Carcinoid tumors

Answer 10

• NOT related to smoking
• have SEPTA*
• neuroendorine -> SEROTONIN
• CARCINOID syndrome (diarrhea, flushing, cyanosis)

Question 11

malignant mesothelioma

Answer 11

• type of pleural tumor
• from ASBESTOS
• CDKN2A/INK4a tumor suppressor deletion