HEENT disorders Flashcards
Acute rhinosinusitis defined
inflammation of the mucosal lining of nasal passages and paranasal sinuses lasting up to 4 weeks
can be cause by allergens, virus, bacteria and fungi
Acute bacterial rhinosinusisits defined
secondary bacterial infection of paranasal sinuses following a viral URI
“sinus infection”
What questions to ask prior to antimicrobial therapy
what are the most likely pathogens
what is the spectrum of the given antimicrobial
what is the likelihood of the resistant pathogen
what is the danger if there is tx failure
Pathogens that cause acute bacterial rhinosinusitis
S. pneumoniae (most common)
H. influenzae (common cause of recurrent infections and those who are tobacco users
M. cat (least common)
S. pneumoniae description
gram pos diplococci
H. influenza description
gram neg bacillus
M. cat description
gram neg coccus
drug resistance in s. pneumonia
> 25% drug resistance from altered protein binding and can limits its ability to bind to pathogen
drug resistance to h. influenza
> 30% PCN resistant from production of beta-lactamase
drug resistance to m. cat
> 90% PCN resistance from beta-lactamase
Risk factors for abx resistance
age < 2 and >65 daycare prior abx within past month comorbidities immunocompromised
Needing Abx therapy without risk for resistance
start first line antimicrobial and do 5-7 days
Needing abx therapy with risk of resistance
start 2nd line antimicorbial and do for 7-10 days
First line therapy for ABRS (bacterial sinusitis)
High dose Amox 3-4g/day
Amox-clavulanate (augmentin) 500/125 TID
Amox-clavulanate (augmentin) 875/125 BID
What does claculanate do with drug resistance?
it is a beta lactamase inhibitor and allows amox to have activity against beta lactamase producting organisms such as h.influenza and m. cat
Second line therapy for ABRS
Amox-clavulanate 2000/125 PO BID
Doxy 100 mg PO BID
Doxy cautions
Pregnancy category D
Can stain teeth
sit upright 30 minutes following taking
Tx choices for ABRS with beta-lactam allergy
Doxy
Levofloxacin 500 daily
moxifloxacin 400 daily
(these are active against drug resistant s. pneumo, gram neg and are stable in presence of beta lactamase
Tx choice for abx resistance or failed initial therapy
Amox-clavulanate 2000/125 BID
Levofloxacin 500 daily
moxifloxacin 400 daily
Trimethoprim-sulfamethoxazole for ABRS
bactrim
not a good option, does not always cover
3 questions to ask when choosing abx therapy
Is it gram pos or neg?
Is it safe?
Is it stable in beta lactamase
S/S of otitis externa
erythema of external ear
discomfort when tragus is pulled
Normal finding with unilateral AOM with ear fullness
weber test lateralization to the affected ear
shows conductive hearing loss
ear fullness is a normal finding
hearing loss associated with presbycuis presentation
age r/t slowly progressive symmetic high frequency "sensoryneural"
Controller medications for allergic rhinitis
intranasal corticosteroids
leukotriene receptor antagonist/modifiers
mast cell stabilizers both intranasal and ophthalmic
Intranasal corticosteroids used for allergic rhinitis
beclomethasone budesonide ciclesonide flunisolide fluticason triamcinolone "the ides and one's"
Leukotriene receptor antagonists/modifiers used for allergic rhinitis
montelukast (Singulair)
Intranasal mast cell stabilizers for AR
cromolyn
safe and less effective than corticosteroids
Opthalmic mast cell stabilizers for AR
cromolyn
nedocromil
improves when combined with antihistamines
Use of intranasal corticosteroids
can cause nasal irritation and bleeding
some systemic bioavailability in elderly
takes 1-2 weeks to reach optimal efficacy
can be used in acute sinusitis
1st generation antihistamines for reliever meds for AR
diphenhydromine chlorpheniramine hydroxyzine block histamine 1 receptors have anticholinergic effects
2nd generation antihistamines for reliever meds for AR
loratadine desloratadine cetirizine (zyrtec) levocetirizine fexofendadine (Allegra) better than 1st generation little benefit with nasal congestion
nasal antihistamines for reliever meds for AR
azelastine
olopatadine
for non-allergic AR and nasal congestion
systemic absorption so drowzy
opthalmic antihistamines for relieve meds for AR
olopatadine
azelastine
bepotastine
for ocular allergy symptoms