Heavy Metal Toxicity Drugs Flashcards
1
Q
Deferoxamine
A
binds Fe
short half life
treats Fe overload (from beta-thalassemia major and repeated blood transfusions)
2
Q
Penicillamine
A
chelating agent (best for Cu) treats Wilson's disease (Cu overload)
3
Q
EDTA
A
chelating agent for Pb and Hg, takes up Ca too.
-treats Pb toxicity
4
Q
CaNa2EDTA
A
EDTA + Ca to prevent too much Ca chelation
5
Q
dimercaprol = BAL
A
binds heavy metals, treats Pb and Hg toxicity, a toxic drug
6
Q
DMSA:
A
specific for heavy metals, less toxic
-treats Pb and Hg toxicity
7
Q
Selenium
A
conjugates with Arsenic and glutathione to facilitate biliary elimination of As
8
Q
folate
A
facilitates methylation of As to increase renal excretion
