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Pharmacology > Cytochrome P450 enzymes > Flashcards

Cytochrome P450 enzymes Flashcards

1
Q

CYP 1A2

A

inducer: tobacco, inhibitor: cimetidine
metabolizes: caffeine

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2
Q

CYP2C19:

A

inducer: prednisone, inhibitor: ketoconazole
- metabolizes: omeprazole,
13-20% of Asians have no CYP2C19 (CYP2C19*2 or *3 = null)

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3
Q

CYP2C9

A

inducer: rifampin
metabolizes: warfarin, tamoxifen, ibuprofen

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4
Q

CYP2D6

A

inducer: dexamethasone, inhibitor: cimetidine
-30% of Ethiopian/Saudis have CYP2D6*2xN (more than 2 alleles) : req higher doses
metabolizes:

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5
Q

CYP 2E1

A

inducer: EtOh, inhibitor: water cress

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6
Q

CYP 3A4,5,7

A

inducer: barbiturates; inhibitors: cimetidine, grapefruit juice, erythromycin, verapamil
metabolizes: cyclosporin, majority of drugs

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7
Q

CYP2A6

A

metabolizes: nicotine

- 15% of Asians have CYP2A6del (deletion)

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Pharmacology (8 decks)

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