Heart Failure Management

Question 1

why we give diuretics ?

Answer 1

it decrease the preload and torsomid has Anti fibrotic effect

Question 2

whats the long standing effect of the diuretics ?

Answer 2

it decrease the renal blood flow and causes estimation odf the renin angiotensin activity

Question 3

thiazides diuretics could why it doesn’t use any more ?

and what it type

Answer 3

it causes dermatological cancer

and we have Moduritcs and natriuretic which most often use because it has vasodilator effect

Question 4

what’re ht most characteristic features of the thiazide ?

Answer 4

it has diuretics effect

and vasodilator effect

Question 5

thiazide mechanism of action

Answer 5

inhibiting reabsorption of sodium (Na+) and chloride (Cl−) ions from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na+-Cl− symporter.

Question 6

Mechanism of action of the spironolactone ?

Answer 6

a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.

Question 7

what’re the side effect of the spironolactone ?

Answer 7

• it should taken with the meal so we can avoid the esophageal irritation
• it cause gynecomastia and impatience

Question 8

why we give spironolactone of HF pt and causes gynecomastia and impotence and irritation ?

Answer 8

because

• it k sparing
• and increase the 5 years survival because it works against the aldosterone which is potent fibrosis

Question 9

mechanism of action of the digoxin ?

Answer 9

-inhibition of the sodium potassium adenosine triphosphatase (Na+/K+ ATPase), mainly in the myocardium

• decrease the heart rate
• increase the automaticity of the heart
• increase the well being so decrease the days of hospitalization

Question 10

complication of digoxin ?

Answer 10

1- arrhythmia 
2- nephrotoxic 
3-neusea  and vomiting 
4- gynecomastia 
5-xerphilia

Question 11

does beta blocker improve 5 years survival ?

Answer 11

yes, because its affect the sympathetic system and antiplatlete and on renin