community aquired pnemonia _ احمد عبيد Flashcards

1
Q

what’s the “Pneumonia” ?

A

Pneumonia is an acute respiratory illness +

recently developed radiological pulmonary shadowing,

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2
Q

what’re the type of “Pneumonia”or the radiological shadowing ?

A

may be
1-segmental
2- lobar
3-or multilobar

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3
Q

classification of “Pneumonia” ?

A

1-Community- Or

2- Hospital-acquired

3-Pneumonia in immuno-compromised hosts.

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4
Q

‘Lobar pneumonia is

A

radiological and pathological term referring
to **homogeneous consolidation **

***one or more lung lobes,

*** often with associated pleural inflammation.

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5
Q

‘Bronchopneumonia’ refer to

A

more ***patchy alveolar consolidation

**often affecting both lower lobes

**associated with bronchial and bronchiolar inflammation, .

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6
Q

inflammatory response in lobar pneumonia ?

A

the alveolar units are flooded by a proteinaceous exudate & by neutrophils, red blood cells, & numerous pneumococci may be observed.

As fibrin forms, on the cut surface of the affected lobe, it resembles liver
3rd stage,(‘grey hepatisation’)
As congestion resolves, the lung tissue becomes grey

4th stage (resolution  )
------------------
, clearance and repair mechanisms restore the normal architecture of the lung.  (resolution  )
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7
Q

Community-acquired pneumonia Accounting for in LRTI?

A

around 5–12%

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8
Q

Community-acquired pneumonia affect which age group ?

A

Affects all age groups but is common at the extremes of age it’s called old man

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9
Q

Community-acquired pneumonia spread by ?

A

droplet infection, in most cases

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10
Q

Community-acquired pneumonia most common agent ?

A

Streptococcus pneumoniae

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11
Q

which factor point on the organism ?

A

Age & the clinical context, point to that other organisms

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12
Q

Adult CAP increasingly recognized caused by

A

by viral infection

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13
Q

Factors that predispose to Pneumonia ?

A

1-Old age
2-Cigarette smoking
3-Alcohol
4-Corticosteroid therapy

5-Pre-existing lung disease
6-Upper respiratory tract infections
7-Recent influenza infection
8-HIV

9-Indoor air pollution

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14
Q

Organisms causing CAP bacterial?

A
.Streptococcus pneumoniae
• Mycoplasma pneumoniae
• Legionella pneumophila
• Chlamydia pneumoniae
• Haemophilus influenzae
• Staphylococcus aureus
• Chlamydia psittaci
• Coxiella burnetii (Q fever,)
• Klebsiella pneumoniae
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15
Q

Organisms causing CAP viral ?

A
  • Influenza, parainfluenza
  • Measles
  • Herpes simplex
  • Varicella
  • Adenovirus
  • Cytomegalovirus (CMV)
  • Coronavirus
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16
Q

what’s the Clinical Context means ?

A

means ‘best guess’ as to the likely organism may be made from the context in which pneumonia develops,

but not from the clinical & radiological picture, which does not differ sufficiently from one organism to another

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17
Q

Mycoplasma pneumoniae is more common in

A

young & rare in the elderly.

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18
Q

Haemophilus influenzae is more common in

A

in the elderly, when underlying lung disease is present.

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19
Q

Legionella pneumophila

A

occurs in local outbreaks centred on contaminated cooling system.

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20
Q

Staphylococcus aureus is more common

A

following an episode of influenza

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21
Q

Foreign Travel

A

facilitates the spread of illnesses such as severe acute respiratory syndrome (SARS), caused by coronavirus

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22
Q

lobar pneumonia, usually presents as

A

lobar pneumonia, usually presents as an acute illness.

1-Systemic features: fever, rigors, shivering and malaise and delirium, appetite is invariably lost & headache frequently reported.

2-Pulmonary symptoms: cough, which at first is short, painful & dry, but later accompanied by the expectoration of muco-purulent sputum.

2-Rust-coloured sputum: Strep. Pneumoniae & occasional haemoptysis.

3-Pleuritic chest pain may be a presenting feature , referred to shoulder or anterior abdominal wall, in lober penu.

4-Upper abdominal tenderness lower lobe pneumonia or if there is associated hepatitis.

4-Less typical presentations may be seen in very young & elderly.

rust colored – usually caused by pneumococcal bacteria (in pneumonia), pulmonary embolism, lung cancer or pulmonary tuberculosis. Brownish – chronic bronchitis (greenish/yellowish/brown); chronic pneumonia (whitish-brown); tuberculosis; lung cancer. Yellow, yellowish purulent – containing pus

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23
Q

Rust-coloured sputum caused by

A

Strep. Pneumoniae

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24
Q

Less typical presentations may be seen in

A

in very young & elderly.

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25
examination
symptoms --------------------- 1-R. Rate & P. Rate raised 2- Blood pressure decrease 3- Mental state reveal delirium. 4-Pyrexia is clue if present. 5-. Cyanosed & Distressed Oxygen saturation low signs -------------- 1-Chest signs vary, depending on the phase 2-consolidated, the lung is: dull to percussion , as conduction of sound is enhanced 3- Auscultation -bronchial breathing -whispering pectoriloquy refers to an increased loudness of whispering noted during auscultation -crackles are heard throughout. But, in many patients, signs are more subtle with reduced air entry only, but crackles are usually present ولكن ، في العديد من المرضى ، تكون العلامات أكثر دقة مع انخفاض دخول الهواء فقط ، ولكن عادة ما تكون الطقطقة
26
aim of Investigations
1-confirm the diagnosis 2-exclude other conditions 3-assess the severity 4-identify the development of complications.
27
Investigations are
Blood test : ----------------------- 1-Full blood count • white cell count Very high (> 20 × 109/L) or low (< 4 × 109/L) : marker of severity * Neutrophil leucocytosis > 15 × 109/L: suggests bacterial aetiology * Haemolytic anaemia: occasional complication of Mycoplasma * Urea > 7 mmol/L : marker of severity * Hyponatraemia: marker of severity Liver function tests ---------------------------------- * Abnormal if basal pneumonia inflames liver * Hypoalbuminaemia: marker of severity Erythrocyte sedimentation rate/C-reactive protein ------------------------------------------------------------------------- • Non-specifically elevated Blood culture Bacteraemia: ------------------------------------------ marker of severity Serology Acute & convalescent titres -------------------------------------------------------- for Mycoplasma, Chlamydia, Legionella & viral infections Cold agglutinins -------------------------- Positive in 50% of patients with Mycoplasma P. Arterial blood gases ------------------------------------- Measure when SaO2 < 93% or when severe clinical features to assess ventilatory failure or acidosis Sputum: ------------------ Sputum samples Gram stain, culture & antimicrobial sensitivity testing Oro pharynx swab -------------------------------------- PCR --------------- for Mycoplasma pneumoniae & other atypical pathogens Urine Antigen/ ----------------- Legionella antigen Serum antign --------------- / Pneumococcal Chest X-ray -------------------
28
what're the marker of severity in CAP?
white cell count Very high (> 20 × 109/L) or low (< 4 × 109/L) : marker of severity Urea > 7 mmol/L : marker of severity Hyponatraemia: marker of severity Hypoalbuminaemia: marker of severity Blood culture
29
Serology Acute & convalescent titres FOR
for Mycoplasma, Chlamydia, Legionella & viral infections
30
Cold agglutinins for
Positive in 50% of patients with Mycoplasma P.
31
Arterial blood gases for
Measure when SaO2 < 93% or when severe clinical features to assess ventilatory failure or acidosis
32
Sputum for
Gram stain, culture antimicrobial sensitivity testing
33
PCR for
for Mycoplasma pneumoniae & other atypical pathogens
34
Urine Antigen for
Legionella antigen
35
Serum antign
Pneumococcal
36
Chest X-ray OF Lobar pneumonia?
* Patchy opacification evolves into homogeneous consolidation of affected lobe * Air bronchogram (air-filled bronchi appear lucent against consolidated lung tissue) +Air bronchogram refers to the phenomenon of air-filled bronchi (dark) being made visible by the opacification of surrounding alveoli (grey/white). It is almost always caused by a pathologic airspace/alveolar process, in which something other than air fills the alveoli.
37
Chest X-ray OF Bronchopneumonia ?
Typically patchy and segmental shadowing
38
Chest X-ray OF Staph. aureus | ?
Multilobar shadowing, cavitation, pneumatocoeles & abscesses
39
Chest X-ray OF Pleural fluid ?
Always aspirate and culture when more than trivial amounts, with ultrasound guidance
40
chest x ray will show ?
1-Lobar pneumonia 2-Bronchopneumonia 3-Complications • Para-pneumonic effusion, intrapulmonary abscess or empyema 4-Staph. aureus 5-Pleural fluid
41
Management pf CAP ?
The most important aspects of management are : Oxygenation fluid balance antibiotic therapy In severe or prolonged illness, nutritional support.
42
Oxygen indcation ?
1-tachypnoea, hypoxaemia, hypotension or acidosis, with the aim of maintaining the PaO2 at or above (60 mmHg) or SaO2 at or above 92%. 2-High concentrations (35% or more), & humidified, should be used in all patients who do not have hypercapnia associated with COPD. 3-Continuous positive airway pressure (CPAP) in those who remain hypoxic, (managed in intensive care) . 4- Indications for referral to the intensive therapy unit (ITU) 5-CURB score of 4–5. 6-failing to respond rapidly to initial management
43
Oxygen indcation ?
1-tachypnoea, hypoxaemia, hypotension or acidosis, with the aim of maintaining the PaO2 at or above (60 mmHg) or SaO2 at or above 92%. 2-High concentrations (35% or more), & humidified, should be used in all patients who do not have hypercapnia associated with COPD. 3-Continuous positive airway pressure (CPAP) in those who remain hypoxic, (managed in intensive care) . 4- Indications for referral to the intensive therapy unit (ITU) 5-CURB score of 4–5. 6-failing to respond rapidly to initial management +CURB-65 Score for Pneumonia Severity
44
CURB- 65 score
Confusion* * Urea > 7 mmol/L * Respiratory rate >30/min • Blood pressure systolic <90 or diastolic < 60 • Age > 65 years
45
0 or 1 | of CRUB
Likely to be suitable for home treatment
46
2
Consider hospital-supervised treatment Options may include • Short-stay inpatient • Hospital-supervised outpatient
47
3
Manage in hospital as severe pneumonia Assess for ICU admission, especially if CURB-65 score = 4 or 5
48
Indications for referral to ITU
Persisting hypoxia (PaO2 < 8 kPa (60 mmHg) w O2. Progressive hypercapnia Severe acidosis Circulatory shock Reduced conscious level
49
Intravenous fluids indication ?
These should be considered in patients with: severe illness older patients those who are vomiting Otherwise, an adequate oral intake of fluid encouraged. Inotropic support may be required in patients with shock
50
The initial choice of antibiotic is guided by:
clinical context severity assessment local knowledge of antibiotic resistance
51
In most uncomplicated pneumonia, a 7-day course is adequate but longer in those with
Legionella, staphylococcal or Klebsiella pneumonia
52
Oral antibiotics are usually adequate unless
severe illness | impaired consciousness
53
Antibiotic treatment for CAP for uncomplicated ?
Amoxicillin 500 mg 3 times daily orally
54
If patient is allergic to penicillin
Clarithromycin 500 mg twice daily or Erythromycin 500 mg 4 times daily orally
55
If Staphylococcus is cultured or suspected in CAP ?
* Flucloxacillin 1–2 g 4 times daily IV plus | * Clarithromycin 500 mg twice daily IV
56
If Mycoplasma or Legionella suspected in CAP ?
Clarithromycin 500 mg twice daily orally or IV or Erythromycin 500 mg 4 times daily orally IV plus Rifampicin 600 mg twice daily IV in severe cases
57
Severe CAP
Clarithromycin 500 mg twice daily IV or Erythromycin 500 mg 4 times daily IV plus • Co-amoxiclav 1.2 g 3 times daily IV or Ceftriaxone 1–2 g daily IV or Cefuroxime 1.5 g 3 times daily IV or • Amoxicillin 1 g 4 times daily IV plus flucloxacillin 2 g 4 times daily IV
58
pleural pain treatment
may prevent the patient from breathing normally & coughing efficiently. For the majority: 1-analgesia with paracetamol, co-codamol or NSAIDs is sufficient. 2-opiates if required, used with extreme caution in patients with poor respiratory function, as may suppress ventilation. 3-Physiotherapy is not usually indicated in patients with CAP, but may help expectoration in those with suppress cough because of pleural pain.
59
Most patients respond promptly to antibiotic therapy. But --------------- may persist for several days.
fever
60
chest X-ray often takes several weeks , especially in ------------
old age
61
Delayed recovery suggests either
a complication incorrect diagnosis secondary to a proximal bronchial obstruction recurrent aspiration
62
The mortality rate of adults with non-severe pneumonia
adults with non-severe pneumonia is very low (< 1%) hospital death rates are typically between 5 & 10% but may be as high as 50% in severe illness.
63
Complications of pneumonia
- Para-pneumonic effusion common - Empyema - Retention of sputum causing lobar collapse - Deep vein thrombosis and pulmonary embolism - Pneumothorax, particularly with Staph. aureus - Suppurative pneumonia/lung abscess - ARDS, renal failure, multi-organ failure - Ectopic abscess formation (Staph. aureus) - Hepatitis, pericarditis, myocarditis, meningo-encephalitis - Pyrexia due to drug hypersensitivity