community aquired pnemonia _ احمد عبيد Flashcards

1
Q

what’s the “Pneumonia” ?

A

Pneumonia is an acute respiratory illness +

recently developed radiological pulmonary shadowing,

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2
Q

what’re the type of “Pneumonia”or the radiological shadowing ?

A

may be
1-segmental
2- lobar
3-or multilobar

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3
Q

classification of “Pneumonia” ?

A

1-Community- Or

2- Hospital-acquired

3-Pneumonia in immuno-compromised hosts.

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4
Q

‘Lobar pneumonia is

A

radiological and pathological term referring
to **homogeneous consolidation **

***one or more lung lobes,

*** often with associated pleural inflammation.

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5
Q

‘Bronchopneumonia’ refer to

A

more ***patchy alveolar consolidation

**often affecting both lower lobes

**associated with bronchial and bronchiolar inflammation, .

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6
Q

inflammatory response in lobar pneumonia ?

A

the alveolar units are flooded by a proteinaceous exudate & by neutrophils, red blood cells, & numerous pneumococci may be observed.

As fibrin forms, on the cut surface of the affected lobe, it resembles liver
3rd stage,(‘grey hepatisation’)
As congestion resolves, the lung tissue becomes grey

4th stage (resolution  )
------------------
, clearance and repair mechanisms restore the normal architecture of the lung.  (resolution  )
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7
Q

Community-acquired pneumonia Accounting for in LRTI?

A

around 5–12%

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8
Q

Community-acquired pneumonia affect which age group ?

A

Affects all age groups but is common at the extremes of age it’s called old man

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9
Q

Community-acquired pneumonia spread by ?

A

droplet infection, in most cases

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10
Q

Community-acquired pneumonia most common agent ?

A

Streptococcus pneumoniae

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11
Q

which factor point on the organism ?

A

Age & the clinical context, point to that other organisms

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12
Q

Adult CAP increasingly recognized caused by

A

by viral infection

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13
Q

Factors that predispose to Pneumonia ?

A

1-Old age
2-Cigarette smoking
3-Alcohol
4-Corticosteroid therapy

5-Pre-existing lung disease
6-Upper respiratory tract infections
7-Recent influenza infection
8-HIV

9-Indoor air pollution

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14
Q

Organisms causing CAP bacterial?

A
.Streptococcus pneumoniae
• Mycoplasma pneumoniae
• Legionella pneumophila
• Chlamydia pneumoniae
• Haemophilus influenzae
• Staphylococcus aureus
• Chlamydia psittaci
• Coxiella burnetii (Q fever,)
• Klebsiella pneumoniae
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15
Q

Organisms causing CAP viral ?

A
  • Influenza, parainfluenza
  • Measles
  • Herpes simplex
  • Varicella
  • Adenovirus
  • Cytomegalovirus (CMV)
  • Coronavirus
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16
Q

what’s the Clinical Context means ?

A

means ‘best guess’ as to the likely organism may be made from the context in which pneumonia develops,

but not from the clinical & radiological picture, which does not differ sufficiently from one organism to another

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17
Q

Mycoplasma pneumoniae is more common in

A

young & rare in the elderly.

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18
Q

Haemophilus influenzae is more common in

A

in the elderly, when underlying lung disease is present.

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19
Q

Legionella pneumophila

A

occurs in local outbreaks centred on contaminated cooling system.

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20
Q

Staphylococcus aureus is more common

A

following an episode of influenza

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21
Q

Foreign Travel

A

facilitates the spread of illnesses such as severe acute respiratory syndrome (SARS), caused by coronavirus

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22
Q

lobar pneumonia, usually presents as

A

lobar pneumonia, usually presents as an acute illness.

1-Systemic features: fever, rigors, shivering and malaise and delirium, appetite is invariably lost & headache frequently reported.

2-Pulmonary symptoms: cough, which at first is short, painful & dry, but later accompanied by the expectoration of muco-purulent sputum.

2-Rust-coloured sputum: Strep. Pneumoniae & occasional haemoptysis.

3-Pleuritic chest pain may be a presenting feature , referred to shoulder or anterior abdominal wall, in lober penu.

4-Upper abdominal tenderness lower lobe pneumonia or if there is associated hepatitis.

4-Less typical presentations may be seen in very young & elderly.

rust colored – usually caused by pneumococcal bacteria (in pneumonia), pulmonary embolism, lung cancer or pulmonary tuberculosis. Brownish – chronic bronchitis (greenish/yellowish/brown); chronic pneumonia (whitish-brown); tuberculosis; lung cancer. Yellow, yellowish purulent – containing pus

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23
Q

Rust-coloured sputum caused by

A

Strep. Pneumoniae

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24
Q

Less typical presentations may be seen in

A

in very young & elderly.

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25
Q

examination

A

1-R. Rate & P. Rate raised

2- Blood pressure decrease

3- Mental state reveal delirium.

4-Pyrexia is clue if present.

5-. Cyanosed & Distressed
Oxygen saturation low

1-Chest signs vary, depending on the phase

2-consolidated, the lung is: dull to percussion , as conduction of sound is enhanced

3- Auscultation
-bronchial breathing

-whispering pectoriloquy
refers to an increased loudness of whispering noted during auscultation
-crackles are heard throughout.

But, in many patients, signs are more subtle with reduced air entry only, but crackles are usually present

ولكن ، في العديد من المرضى ، تكون العلامات أكثر دقة مع
انخفاض دخول الهواء فقط ، ولكن عادة ما تكون الطقطقة

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26
Q

aim of Investigations

A

1-confirm the diagnosis
2-exclude other conditions
3-assess the severity
4-identify the development of complications.

27
Q

Investigations are

A

1-Full blood count
• white cell count Very high (> 20 × 109/L) or low (< 4 × 109/L) : marker of severity

  • Neutrophil leucocytosis > 15 × 109/L: suggests bacterial aetiology
  • Haemolytic anaemia: occasional complication of Mycoplasma
  • Urea > 7 mmol/L : marker of severity
  • Hyponatraemia: marker of severity

  • Abnormal if basal pneumonia inflames liver
  • Hypoalbuminaemia: marker of severity

• Non-specifically elevated

marker of severity

for Mycoplasma, Chlamydia, Legionella & viral infections

Positive in 50% of patients with Mycoplasma P.

Measure when SaO2 < 93% or when severe clinical features to assess ventilatory failure or acidosis

Sputum samples Gram stain, culture & antimicrobial sensitivity testing

for Mycoplasma pneumoniae & other atypical pathogens

Legionella antigen

/ Pneumococcal

28
Q

what’re the marker of severity in CAP?

A

white cell count Very high (> 20 × 109/L) or low (< 4 × 109/L) : marker of severity

Urea > 7 mmol/L : marker of severity

Hyponatraemia: marker of severity

Hypoalbuminaemia: marker of severity

Blood culture

29
Q

Serology Acute & convalescent titres FOR

A

for Mycoplasma, Chlamydia, Legionella & viral infections

30
Q

Cold agglutinins for

A

Positive in 50% of patients with Mycoplasma P.

31
Q

Arterial blood gases for

A

Measure when SaO2 < 93% or when severe clinical features to assess ventilatory failure or acidosis

32
Q

Sputum for

A

Gram stain,
culture
antimicrobial sensitivity testing

33
Q

PCR for

A

for Mycoplasma pneumoniae & other atypical pathogens

34
Q

Urine Antigen for

A

Legionella antigen

35
Q

Serum antign

A

Pneumococcal

36
Q

Chest X-ray OF Lobar pneumonia?

A
  • Patchy opacification evolves into homogeneous consolidation of affected lobe
  • Air bronchogram (air-filled bronchi appear lucent against consolidated lung tissue)

+Air bronchogram refers to the phenomenon of air-filled bronchi (dark) being made visible by the opacification of surrounding alveoli (grey/white). It is almost always caused by a pathologic airspace/alveolar process, in which something other than air fills the alveoli.

37
Q

Chest X-ray OF Bronchopneumonia ?

A

Typically patchy and segmental shadowing

38
Q

Chest X-ray OF Staph. aureus

?

A

Multilobar shadowing, cavitation, pneumatocoeles & abscesses

39
Q

Chest X-ray OF Pleural fluid ?

A

Always aspirate and culture when more than trivial amounts, with ultrasound guidance

40
Q

chest x ray will show ?

A

1-Lobar pneumonia

2-Bronchopneumonia

3-Complications
• Para-pneumonic effusion, intrapulmonary abscess or empyema

4-Staph. aureus

5-Pleural fluid

41
Q

Management pf CAP ?

A

The most important aspects of management are :

Oxygenation
fluid balance
antibiotic therapy
In severe or prolonged illness, nutritional support.

42
Q

Oxygen indcation ?

A

1-tachypnoea, hypoxaemia, hypotension or acidosis, with the aim of maintaining the PaO2 at or above (60 mmHg) or SaO2 at or above 92%.

2-High concentrations (35% or more), & humidified, should be used in all patients who do not have hypercapnia associated with COPD.

3-Continuous positive airway pressure (CPAP) in those who remain hypoxic, (managed in intensive care) .

4- Indications for referral to the intensive therapy unit (ITU)

5-CURB score of 4–5.

6-failing to respond rapidly to initial management

43
Q

Oxygen indcation ?

A

1-tachypnoea, hypoxaemia, hypotension or acidosis, with the aim of maintaining the PaO2 at or above (60 mmHg) or SaO2 at or above 92%.

2-High concentrations (35% or more), & humidified, should be used in all patients who do not have hypercapnia associated with COPD.

3-Continuous positive airway pressure (CPAP) in those who remain hypoxic, (managed in intensive care) .

4- Indications for referral to the intensive therapy unit (ITU)

5-CURB score of 4–5.

6-failing to respond rapidly to initial management

+CURB-65 Score for Pneumonia Severity

44
Q

CURB- 65 score

A

Confusion*

  • Urea > 7 mmol/L
  • Respiratory rate >30/min

• Blood pressure
systolic <90 or
diastolic < 60

• Age > 65 years

45
Q

0 or 1

of CRUB

A

Likely to be suitable for home treatment

46
Q

2

A

Consider hospital-supervised treatment
Options may include
• Short-stay inpatient
• Hospital-supervised outpatient

47
Q

3

A

Manage in hospital as severe pneumonia
Assess for ICU admission,
especially if CURB-65 score = 4 or 5

48
Q

Indications for referral to ITU

A

Persisting hypoxia (PaO2 < 8 kPa (60 mmHg) w O2.

Progressive hypercapnia

Severe acidosis

Circulatory shock

Reduced conscious level

49
Q

Intravenous fluids indication ?

A

These should be considered in patients with:
severe illness
older patients
those who are vomiting

Otherwise, an adequate oral intake of fluid encouraged.
Inotropic support may be required in patients with shock

50
Q

The initial choice of antibiotic is guided by:

A

clinical context
severity assessment
local knowledge of antibiotic resistance

51
Q

In most uncomplicated pneumonia, a 7-day course is adequate but longer in those with

A

Legionella, staphylococcal or Klebsiella pneumonia

52
Q

Oral antibiotics are usually adequate unless

A

severe illness

impaired consciousness

53
Q

Antibiotic treatment for CAP for uncomplicated ?

A

Amoxicillin 500 mg 3 times daily orally

54
Q

If patient is allergic to penicillin

A

Clarithromycin 500 mg twice daily or Erythromycin 500 mg 4 times daily orally

55
Q

If Staphylococcus is cultured or suspected in CAP ?

A
  • Flucloxacillin 1–2 g 4 times daily IV plus

* Clarithromycin 500 mg twice daily IV

56
Q

If Mycoplasma or Legionella suspected in CAP ?

A

Clarithromycin 500 mg twice daily orally or IV or

Erythromycin 500 mg 4 times daily orally IV plus

Rifampicin 600 mg twice daily IV in severe cases

57
Q

Severe CAP

A

Clarithromycin 500 mg twice daily IV or Erythromycin
500 mg 4 times daily IV plus

• Co-amoxiclav 1.2 g 3 times daily IV or Ceftriaxone 1–2 g
daily IV or Cefuroxime 1.5 g 3 times daily IV or

• Amoxicillin 1 g 4 times daily IV plus flucloxacillin 2 g 4 times daily IV

58
Q

pleural pain treatment

A

may prevent the patient from breathing normally & coughing efficiently.
For the majority:

1-analgesia with paracetamol, co-codamol or NSAIDs is sufficient.

2-opiates if required, used with extreme caution in patients with poor respiratory function, as may suppress ventilation.

3-Physiotherapy is not usually indicated in patients with CAP, but may help expectoration in those with suppress cough because of pleural pain.

59
Q

Most patients respond promptly to antibiotic therapy. But ————— may persist for several days.

A

fever

60
Q

chest X-ray often takes several weeks , especially in ————

A

old age

61
Q

Delayed recovery suggests either

A

a complication
incorrect diagnosis
secondary to a proximal bronchial obstruction
recurrent aspiration

62
Q

The mortality rate of adults with non-severe pneumonia

A

adults with non-severe pneumonia is very low (< 1%)

hospital death rates are typically between 5 & 10%

but may be as high as 50% in severe illness.

63
Q

Complications of pneumonia

A
  • Para-pneumonic effusion common
  • Empyema
  • Retention of sputum causing lobar collapse
  • Deep vein thrombosis and pulmonary embolism
  • Pneumothorax, particularly with Staph. aureus
  • Suppurative pneumonia/lung abscess
  • ARDS, renal failure, multi-organ failure
  • Ectopic abscess formation (Staph. aureus)
  • Hepatitis, pericarditis, myocarditis, meningo-encephalitis
  • Pyrexia due to drug hypersensitivity