Heart Flashcards
Systole
When the heart muscle contracts, ventricular contraction
Aortic and pulm valves open
Systolic pressure
Pressure in arteries when the heart contracts
Diastole
When the heart muscle relaxes, ventricular relaxation
Tricuspid and mitral valve open
Diastolic pressure
Pressure in arteries when the heart rests
End diastolic volume
Volume of blood in LV at the end of diastole (right before it contracts)
End systolic volume
Volume of blood in the LV at the end of systole (ventricular ejection)
Stroke volume
Volume of blood pumped out of the LV during systole (SV=EDV-ESV)
Ejection fraction
% of blood the LV pumps out with each contraction (EF=SV/EDVx100)
Cardiac output
Volume of blood pumped/minute (CO=SVxHR)
Preload
Initial stretching of cardiomyocytes prior to contraction (EDV or pressure)
Afterload
Load heart must eject blood against, related to aortic pressure, ventricular wall stress
Isovolumetric relaxation
Ventricular diastole begins
Ventricles relax but volume of blood does not change because all heart valves are closed and pressure in V is still higher than A
Atrial contraction
End of ventricular diastole, atrial systole
Atria contract to force last of blood into the ventricles
Ventricular filling
Ventricular diastole continues
Pressure in A greater than V so AV valves open and blood flows passively
Isovolumetric contraction
Ventricular systole begins and ventricles contract
V pressure is greater than A so AV valves are closed
Pressure not greater than aorta or pulmonary trunk
Ventricular ejection
Ventricular systole continues
Ventricular contraction continues, pressure is now greater than aorta and pulmonary trunk forcing valves open
P-wave
Atrial depolarization that precedes atrial contraction
QRS complex
Ventricular depolarization right before ventricular contraction
T-wave
Repolarization after ventricular contraction
Covering of the heart
Pericardial sac
Pericardial fluid
Lubricates the heart
Tissues of the parietal pericardium
Fibrous layer and serous layer
Fibrous layer
Dense, connective, collagenous tissue
Prevents overfilling
Serous layer
Makes serous fluid
Fibrous layer location
Outer part of the pericardial sac
Serous layer
Balloon that wraps around the heart, creates two layers
Visceral pericardium
Part of the serous layer, closest part to the heart
Pericardial space
Fluid filled space in serous layers
Chamber of the heart that touches the sternum (anterior)
Right ventricle
Chamber of the heart that touches the esophagus (posterior)
Left atrium
Chamber of the heart that forms the base and touches diaphragm and ribs
Left ventricle
Chamber of the heart that forms the right side of heart
Right atrium
Chordae tenineae
Heart strings that are attached to atrioventricular valves that prevent regurgitation
Papillary muscles
Branching heart muscles that attach to chordae tendineae
S1 sound
Lub
Closing of atrioventricular valves during ventricular systole
S2 sound
Dub
Closing of semilunar valves
Diastole
Right coronary artery
Supplies right side of the heart and starts at right cusp of aortic valve
What the right coronary artery supplies
SA nodal artery
Right (acute) marginal artery
Posterior descending (interventricular) artery
Posterior descending (intraventricular) artery
Supplies posterior IV septum
Left coronary artery
Supplies left side of the heart in the coronary sulcus, branches from left cusp of aortic valve
Left coronary artery branches
Left anterior descending artery
Left circumflex artery
Left anterior descending artery
Supplies anterior IV septum and apex
Left circumflex artery
Supplies the left lateral wall
Coronary dominance
When looking at someone’s heart, where the PDA comes from
58% from RCA
20% from LCA
2% from both R and LCA
Cardiac veins
Coronary sinus
Great cardiac vein
Middle cardiac vein
Small cardiac vein
Coronary sinus
Responsible for draining the deoxygenated blood from the heart into the right atrium
Great cardiac vein function and location
Drains the anterior surface of the LV
Overlays the LAD and drains area that that supplies
Middle cardiac vein
Drains posterior walls and posterior IVS
Overlays the PDA
Small cardiac vein
Drains the posterior section of the heart
Where sympathetic innervation of the heart originates
T1-T5 in the spinal cord
Travel of a sympathetic nerve from spinal cord to the heart
Synapses in the lateral horn, travels out the ventral root into the sympathetic chain where it synapses again
Can travel up or down the symp. trunk to cervical or another T, then travels to the heart and synapses again
Location of parasympathetic innervation of the heart
Brainstem (medulla)
Travel of parasympathetic nerve to the heart
Synapses in the medulla and then travels directly to the heart and synapses again
SA Node
Originates in the RA and starts the depolarization of the heart
60-100bpm
AV node
In between the atrium and ventricles
Slows down signal so atrium fully contract before ventricles contract
40-60bpm
Bundle of his
Receives signal from AV node and rapidly sends down the IV septum into left and right bundle branches
Perkinje fibers
Located by the apex of the heart and wraps around and back up the heart so that the ventricles contract
Reaches papillary muscles first so the valves close before contraction
Systolic murmur
Occur during ventricular contraction
Most common murmurs
Valve stenosis and valve insufficiency
Diastolic murmur
Occur during atrial contraction
Stenosis
Failure of a valve to open completely, impedes forward flow by forcing blood through a smaller opening and the flow becomes turbulent
Insufficiency
Also known as regurgitation
Failure of a valve to close completely allowing reversed flow
Murmur occurs when valve should be shut
Why is the anatomical position important
Need a universal view of the body
What is the anatomical position
Patient facing forward, arms at the side, palms front, thumbs to the side, and pt POV (their left arm)
Anterior
Front
Ventral
Front
Posterior
Back
Dorsal
Back
Superior
Above, towards the top
Inferior
Below, towards the bottom
Cranial
Towards the top
Caudal
Towards the bottom
Medial
Towards midline
Lateral
Away from midline
Superficial
External, close to the surface
Deep
Internal, towards the inside
Proximal
Closer to origin in body
Distal
Further from origin in body
Sagittal plain
Cutting between eyes, left and right parts
Coronal
Also front plane
Cut between the ears, front and back
Transverse plane
Cuts the body into superior and inferior parts
Tissue
Group of related cells organized for a common purpose
Histology
Study of tissues
Color in stains
Pink = proteins
Purple = Nuclei
Types of tissues
Epithelial
Connective
Muscle
Nervous
Epithelium characteristics
Avascular and no extracellular matrix
Anatomy of epithelial tissue
Cells anchored to a basement membrane with apical and basal surfaces
Epithelium location
Forms glandular tissue, lines lumen of tubular organs and body cavities and externally covers the body and organs
Basement membrane
Anchors epithelium to the underlying CT where the capillaries reside
How to classify epithelial tissue
Number of cell layers: Simple vs stratified
Cell shape: squamous, cuboidal, columnar
Cell specialization: cilia or microvili
Cilia
Apical surface of anchored cells and moves liquid over the surface of the cell
Microvili
Apical surface of anchored cells, increases surface area for absorption
Simple squamous epithelium
One layer of flat cells
Simple squamous epithelium location
Alveoli, nephron, endothelium/capillaries, mesothelium lining parietal and visceral serous membranes
Simple squamous epithelium function
Diffusion, filtration, lubrication
Simple cuboidal epithelium
One layer of cubed cells with centrally located circular nucleus
Simple cuboidal epithelium function
Absorption and secretion
Simple cuboidal epithelium location
Renal tubules in nephron, glands, airways, uterus/uterine tubes
Simple columnar epithelium
One layer of tall thin cells with oval nucleus towards basal
Simple columnar epithelium location
Mucosal layer of GI tract, glands, airways, uterus/uterine tube
Simple columnar epithelium function
Absorption and secretion
Stratified squamous epithelium
Multiple layers of flat cells
Stratified squamous epithelium location
Epidermis (keratinized), esophagus and vagina (non-keratinized)
Stratified squamous epithelium function
Protects underlying tissue from abrasion
Transitional epithelium
Multiple layers of dome shaped cells
Transitional epithelium location
Bladder
Transitional epithelium function
Permits stretch in urinary system
Pseudostratified ciliated columnar epithelium
Single layer of cells of differing heights all attached to the basement membrane
Pseudostratified ciliated columnar epithelium location
Also known as respiratory epithelium, trachea and proximal bronchial tree
Pseudostratified ciliated columnar epithelium function
Secretion (mainly mucous), propulsion of mucous by cilia
Connective tissue structure
Small number of cells surrounded by an extracellular matrix, contains fibers and ground substance
Connective tissue embryonic origin
Mesenchyme
Types of connective tissue
Connective tissue proper
Cartilage
Bone
Blood
Connective tissue proper
Consists of loose and dense connective tissues based upon fiber concentration
Cells of the connective tissue proper
Fibroblasts
Adipocytes
Macrophages
Mast cells
Fibroblast
Primary CT cell and synthesizes ECM fibers (collage/elastin) and ground substance
Adipocyte
Fat cells that store lipid in single droplet
Macrophage
Derived from monocyte, phagocytize and destroy microorganisms and damaged tissue
Inflammation, repair, and immune reactions
Mast cell
Abundant in CT that underlies barrier epithelium, detects foreign substances and initiates local inflammation
Extracellular matrix of CTP
Ground substance and fibers
Ground substance
Amorphous material that fills the space between the cells
* Consists of interstitial fluid, fibers, cell adhesion proteins and proteoglycans.
* Holds fluid and functions as sieve through which H2O and solutes diffuse between
capillaries and cells.
Fibers of the CTP
Collagen and elastin
Function of CTP fibers
Provide support
Collagen
Part of the CTP
Tough, structural protein that provides tensile strength
Most abundant protein in the body
Elastin
Part of the CTP
Fiber that allows stretch and recoil in tissues
Snap the collagen fibers back into place after stretching
Types of CTP
Loose CT
Dense irregular CT
Dense regular
Adipose tissue
Loose CT
Deep to all basement membranes
Dense irregular CT function and location
Strong in all directions (dermis and submucosa of tubular organs)
Dense regular CT
Strong in one direction (tendon)
Adipose tissue
Stores energy, padding, insulation (hypodermis, around organs)
Cartilage function
Possesses qualities from CT proper and bone
Flexible, tough, resists tension, twisting, and compressive force
Cartilage cell
Chondrocytes that are surrounded by an ECM
They reside in lacunae embedded in ECM
Types of cartilage
Hyaline cartilage, Fibrocartilage, elastic cartilage
Hyaline cartilage
Most abundant, located in articular cartilage (synovial joints), ribs, nose, etc…
Fibrocartilage
Possesses high concentration of collagen
Located in IV discs, pubic symphysis, menisci
Elastic cartilage location
Least abundant, located in ear and epiglottis
Bone
Composed of hard osseous tissue that supports and protects softer tissue
Attachments for tendons and ligaments
Cavities for fat storage and synthesis of blood cells
Cells of the bone
Osteoblast
Osteocytes
Osteoclasts
Osteoblast
Secretes bone matrix and builds new bone
Osteocyte
Mature osteoblasts that reside in lacunae and monitor and maintain ECM
Osteoclasts
Secrete enzymes that catalyze breakdown of bone matrix
ECM of bone
Consists of calcium and phosphate with collagen
Blood
Fluid connective tissue with cells that are surrounded by ECM
Cells of blood
RBC
WBC
Platelets
RBC
Transports O2
White blood cell
Immune defense
Platelets
Clots blood
Extracellular matrix of bood
Plasma
Muscle tissue structure
Long, thin muscle cells called myofibers of myocytes
Myocytes
Cell of muscle tissue
Striated or smooth depending on presence or absense of repeating arrangements of contractile proteins called myosin and actin
Types of muscle tissue
Skeletal muscle
Cardiac muscle
Smooth muscle
Skeletal muscle
Voluntary muscle with fibers that are long, striated, and multinucleated
Structure of skeletal muscle
Endomysium
Fascicles
Perimysium
Epimysium
Endomysium
Muscle fibers wrapped in this CT
Fascicles
Bundles of muscle fibers that are wrapped in perimysium
Perimysium
Wraps around bundles of muscle fibers
Epimysium
Wraps around all the fascicles and makes up the muscle
Cardiac muscle
Involuntary, striated muscle fibers located in myocardium of the heart
Contains intercalated discs that like cells together
Smooth muscle
Involuntary muscle fibers with no striations located within walls of hollow organs and blood vessels
Function of smooth muscle
Propels substances within these organs by alternately contracting and relaxing and controls BP
Nervous tissue
Comprised of neurons, and neuroglia
Neurons
Send and receive messages and separated by synapses, communicate with NT
Types of neurons
Sensory, motor, interneurons
Sensory neuron
Respond to stimuli (touch, sound) and sends signals to CNS
Motor neuron
Sends impulses away from the CNS to control muscle and glands
Interneurons
Connect neurons to other neurons within the same region of the CNS
Structure of a neuron
Cell body
Dendrites
Axon
Synapses
Neuroglia
Non neuronal cells in the CNS and PNS that provide physical and metabolic support to neurons
Oligodendrocytes
Produce myelin surrounding neuronal axons in the CNS
Schwann cells
Produces myelin surrounding neuronal axons in the PNS
Astrocytes
Star shaped glial cells that regulate transmission of electrical impulses in neurons and support BBB
Ependymal cells
Lines ventricular system of the brain
Microglia
Immune cells that serve as macrophages of the CNS
Stratified squamous non keratinized epithelium
Simple cuboidal
Transitional epithelium
Pseudostratified ciliated columnar epithelium
Skeletal muscle