Heamoglobin

Question 1

Hb

Answer 1

Quaternary struc, heam grouo w iron, high afinnity for O2 eg each mol can carry 4 O2 mol,
Hb dissociates w O2 forms oxhb
Dissociates to release O2

Question 2

Saturation

Answer 2

O2 loads unto hb= oxhb where there high pO2 eg alveloi
Unloads low pO2 eg respiring cells as o2 used up

Question 3

Disociation curve

Answer 3

0 sat= haem centre, low po2= low affinity for o2= release o2 eg repire
100 sat= max, po2 high so high affinity for O2= readily comb
S shape= conformational change
Steep grad= easy for 02 join

Question 4

Co2

Answer 4

Co2 enters rbc+ reacts water= carbonic acid
Dis h+ and hcb ions
H+ binds to hb= hb acid lowers affinity for 02 so hb releases o2
Chloride ions balance charge as hco3 out

Question 5

Bohr effect

Answer 5

Co2 enters rbc so carbonic acid disocistes h+ which affects ph
Hb unable to hold as much 02 and related where more co2 prod

Question 6

Co2 dissociation curve

Answer 6

Shifts right as co2lev inc
As more o2 released from blood
Low sat of hb w o2 so more o2 released= bohr effect

Question 7

Featal hb

Answer 7

Maternal= low affinity so releases
Diffuses across placenta where po2 low and hb high affibity for o2 to associate