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Medicine - Year 2 > Health and Society (9 and 10) > Flashcards

Health and Society (9 and 10) Flashcards

1
Q

Define hypothetico-deductive reasoning

A

Collecting evidence to support or get rid of a hypothesis

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2
Q

Who is evidence-based decision making based upon?

A

Individual patients

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3
Q

Define background question

What does the question need? e.g.

A

General knowledge

Question root and disorder e.g. what causes cancer

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4
Q

Define foreground question

How do you create the question?

A

Specific knowledge about patient management

PICO

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5
Q

5 stages of creating evidence for practise

A
  1. Identify need for information
  2. Identify best evidence
  3. Critically appraise evidence
  4. Integrate evidence clinically
  5. Evaluate and improve
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6
Q

What is PPE?

A

Personal protective equipment

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7
Q

Common hospital transmitted infection?

A

Norovirus

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8
Q

Define surveillance

A

Systemic collection, analysis and publication of data so appropriate measures can be taken

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9
Q

What is the problem with laboratory testing for infectious disease?

A

It takes a long time but is needed for treatment

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10
Q

2 problems with PHE questionnaires

A

People might not remember

People might not disclose

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11
Q

Define international health

A

Defined by geography (north and south)

Donor > Recipient relationship

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12
Q

Define public health

A

Prevention, equity and scientific approaches to the population e.g. TB DOTS

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13
Q

Define global health

A

Wider determinants and health of the global population

Interdependence, Trans-national

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14
Q

Define interconnection

A

Threats and their nature, distribution and consequences

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15
Q

Define interdependence

A

Distribution of power, responsibility, capacity to respond and disciplines

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16
Q

Give 4 examples of interdependent solution

A

Regulating quality of imported goods
Information about global infectious disease
Sufficient medication, vaccinations and health professionals for a pandemic

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17
Q

Define development aid

A

Donor > Recipient

Charity and dependence

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18
Q

Define international cooperation

A

Independent states > Mutual benefit

Pooled resources and independence

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19
Q

Define global solidarity

A

Every state has shared responsibility and resources

Interdependence

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20
Q

7 global problems affecting everybody

A

Global warming, poverty, inequality, food and water security, war, migration, working conditions

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21
Q

5 roles of global health

A 
Research and guidelines
Clinical care and prevention
Manage cross-national 
Epidemiological
Global solidarity
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22
Q

3 strategic aims of vaccination

2 programmatic aims of vaccination

A

Strategic: eradication of the agent, elimination of the outbreak, protection of the vulnerable

Programmatic: reduce death and infection rates

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23
Q

What does the vaccination theory determine?

A

The number of secondary cases caused by each infectious person

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24
Q

In the vaccination theory, what is R?

A

R = effective reproduction number

Actual average number of secondary cases per primary case in a totally susceptible population

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25
Q

In the vaccination theory, what is Ro?

A

Ro = basic reproductive number

Average number of individuals directly infected by an infectious case during the infectious period, in a totally susceptible population

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26
Q

What is Ro determined by?

A

Microorganism and population

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27
Q

What is Ro proportionate to?

A

Length of time the case remains infectious
Number of contacts the case has with hosts per unit time
Chance of transmitting an infection

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28
Q

How can Ro differ?

A

Different infections in the same population

Same infection in different populations

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29
Q

How do you calculate the effective reproduction number (R)?

A

R = Ro x S

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30
Q

What is the relationship between R and Ro?

A

If the values are equal there is no vaccination (early infection)
If R is smaller, vaccination has taken place

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31
Q

What is the epidemic threshold?

What increases and decreases the number of cases?

A

R = 1
If R increases the number of cases increase
If R decreases the number of cases decrease (this is what we want!)

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32
Q

In the vaccination theory, what is S?

How is it calculated?

A

Susceptible proportion of the population
Defined by the threshold at R = 1

1 = Ro x s
s* = 1/Ro
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33
Q

In the vaccination theory, what is H?

How is it calculated?

A

Herd immunity threshold

H = 1 - S*

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34
Q

What should the herd immunity threshold be?

A

No more than 5% of the population should be susceptible (H = 95%)
Once s greater than 5% then R greater than 1

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35
Q

Define herd immunity

A

A measure of the immunity to a transmissible infection in the whole population
Measures protection to the un-vaccinated and vaccinated

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36
Q

What do you need to decide before making a vaccination? (6)

A

If the disease is a public health concern
If immunisation is the most effective strategy
How much disease will be prevented
Negative effects and public perception
Practicality
What the aim of the vaccination is

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37
Q

Define bad news

A

Any news that drastically and negatively alters the patient’s (or their relatives) view of his or her future

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38
Q

Distancing strategies for breaking bad news (4)

A

Normalisation, Avoidance, Switching subject, False reassurance

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39
Q

Why is breaking bad news hard? (8)

A 
Fear of negative response
Burden of responsibility
Uncertainty about patient expectations
Fear of destroying hope
Not prepared to manage emotions
Embarrassment about giving false hope
Relative involvement
Different cultures, religions and beliefs of patients
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40
Q

Define incidence, outcome and prevalence

A

Incidence: Number of new cancer cases during a specific period in a defined population
Outcome: Mortality rate, death and survival
Prevalence: Burden of disease (incidence, death and ongoing cases)

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41
Q

What happens to disease frequency over time?

Why is this important?

A

Changes over time

Aetiological hypothesis and health care planning

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42
Q

What are the 3 population pyramids?

A

Expanding
Stationary
Contracting

43
Q

What is the 10 year survival rate like for melanoma?

A

Nearly 100%

44
Q

Define childhood cancer

A

Below 14 years

45
Q

Are genetics a big cause of cancer?

A

Yes in children

No in adults (more common to pre-dispose)

46
Q

Define primary, secondary and tertiary prevention

A

Primary: Reducing exposure
Secondary: Identification of pre-clinical disease
Tertiary: Modifies outcomes based on the population

47
Q

Handwritten/Computerised records: how do you know who has seen it?

A

Handwritten: date and sign, known writer
Computerised: audit trail

48
Q

What is the difference between what a GP, Community and Hospital clinical record shows?

A

GP includes information
Community includes work load
Hospital includes imaging

49
Q

What is the problem with hospital record

A

30% are not where they’re meant to be

50
Q

What do community record involve?

A

Prisons, Occupational health, Private sector

51
Q

Explain what an SCR is

A

Summary Care Record
Name, address, DOB, NHS number, Medication and Allergies
Can opt out

52
Q 
How does the clinical record:
1 - Support clinical audit (3)
2 - Facilitate clinical governance (5)
3 - Facilitate risk management (3)
4 - Support clinical research (3)
A

1 - learning and development, targets, analyse clinical processes
2 - audit trail, patient safety, complaints, review, quality improvement
3 - prescription alerts, allergy pop-ups, continuity of care
4 - identify suitable patients, records participation, primary epidemiological research

53
Q

Define body

What is it shaped by?

A

Natural and physical allowing us to do everything we would want and a product of our social environment
Shaped by discourses

54
Q

Define the civilised body

A

Separation of the mind and body

e.g. controlling emotions and hiding natural functions (eating and sleeping)

55
Q

What does our body image represent?

A

Our identity

56
Q

Define a clinically significant body image problem

A

Marked discrepancy between the actual/perceived appearance/function of a body attribute and the individuals ideal

57
Q

2 highest areas of cancer incidence in the UK

A

London and midlands

58
Q

What is the European report on cancer care policies called?

When was it commissioned?

A

Eurocare Report

1990

59
Q

Define cancer network

A

Model for NHS cancer plan

Bringing together every resource

60
Q

What does the Calman-Hine Report state?

When was it commissioned?

A

1995
All patients have access to good quality, standardised patient-centred care from an MDT
Recognition of early signs
Importance of psycho-social needs and patient education

61
Q

What is the difference between a cancer unit and cancer centre?

A

Cancer unit: smaller, diagnostic and common treatment

Cancer centre: larger, rarer and complex treatment

62
Q

Function of an MDT

A

Decide on a management plan, designate a key worker and inform the patient and primary care of that plan
Coordinate care and support the patient

63
Q

What does the NHS Cancer Plan state?

When was it commissioned?

A

2000
Focus on prevention and screening
Tackle inequalities and support networks
Invest in research

64
Q

What legislation followed the NHS Cancer Plan?

A

NICE Improving Outcomes Guidance

Increasing the standard and quality of care

65
Q

What are the 6 stages of the Cancer Reform Strategy?

When was it commissioned?

A

2007

  1. Prevention
  2. Diagnosing cancer earlier (screening and diagnosis)
  3. Improving treatment
  4. Living with and beyond cancer
  5. Reducing cancer inequalities
  6. Delivering care in an appropriate setting
66
Q

What ages are you screened for cervical, breast and bowel cancer?

A

Cervical: 25-49 (3 yrs) 50-64 (5yrs)
Breast: 47-73 (5 times)
Bowel: 50-75

67
Q

5 methods to improve cancer diagnosis

A

National awareness and early diagnostic initiative
National & significant event audit for cancer diagnosis
NAEDI hypothesis (preventing avoidable deaths by late presentation)
Diagnostic interval delays
Awareness campaigns

68
Q

6 ways to ensure better treatment and care

A 
Reduce waiting times
Increase capacity and training
New treatments
Local care and centralised services
Diagnostic tests in GP's
Shift from inpatient to outpatient
69
Q

What was the role of the National Cancer Suvivorship Initiative?
When did it end?

A

Ended in 2013

Partnership with charities, clinicians and patients to improve services and support

70
Q

What does the Improving Outcomes Strategy state?

When was it commissioned?

A

Commissioned in 2011

Prevention, screening and early diagnosis
Improve patient experience and QOL
Better treatments
Reduce inequalities (race, age, gender, disability, LGBT)

71
Q

What was commissioned from 2015-2020?

What does it focus on?

A

Achieving World Class Cancer Outcomes

Independent cancer taskforce focusing n prevention, early diagnosis, technology patient experience and support

72
Q

How common are adverse events from vaccinations?

A

Rare

73
Q

2 things which can affect a vaccines effectiveness?

A

Order in which a vaccination is given

Gender

74
Q

3 things rubella can cause in pregnant women

A

Miscarriage, Stillbirth and Congenital defects

75
Q

5 parental objections to vaccination

A

Disease is not serious (it is, people forget)
Disease is uncommon (bc of vaccinations)
Vaccine ineffective (none 100% but they do work)
Vaccine unsafe (testing)
Better methods (no evidence)

76
Q

What % of vaccination coverage do you need to prevent an outbreak?

A

90%

77
Q

What do you need to be confidence about with diagnostic tests?

A

If the patient is above a threshold to treat or below a threshold to withdraw treatment
Has the patient passed the threshold where intervention is needed?

78
Q

How do you calculate sensitivity

Define sensitivity

A

Number of true positives / All those with the disease

The TRUE POSITIVE RATE
Correctly classifies the people WITH disease

79
Q

How do you calculate specificity

Define specificity

A

Number of true negatives / All those without disease

The TRUE NEGATIVE RATE
Correctly classifies the people WITHOUT disease

80
Q

How do you calculate positive predictive value

Define PPV

A

Number true positives / All those who test positive

If your test is positive, what are the chances you’re ill?

81
Q

How do you calculate negative predictive value

Define NPV

A

Number true negatives / All those who test negative

If your test is negative, what are the chances you’re NOT ill?

82
Q

What does it mean for sensitivity and specificity if tests have a high threshold?

A

Reduced sensitivity as you will diagnose some people who have the disease incorrectly
Increased specificity as people without disease will be diagnosed correctly

83
Q

What does it mean for sensitivity and specificity if tests have a low threshold?

A

Increased sensitivity as you will diagnose people with the disease correctly
Reduced specificity as some people without the disease will be diagnosed incorrectly

84
Q

Which of the 4 values change depending on prevalence

A

Sensitivity and specificity DO NOT change

If prevalence is increased, increased NPV and reduced PPV (test is more likely to be wrong when positive and right when negative)

85
Q

3 ways which prevalence changes

A

Between primary and secondary care
Age
Country

86
Q

Define likelihood ratio

A

Assesses how the chances of disease change after a test

87
Q

How do you calculate the likelihood ratio for a positive AND negative test result?

A

Chance test positive if disease /
Chance test positive if well

Chance test negative if disease /
Chance test negative if well

88
Q

How do you calculate chance?

A

e. g. true or false positive / all those who test positive

e. g. true or false negative / all those who test negative

89
Q

What does it mean if you have a larger / smaller likelihood ratio?

A

Larger: GREATER chance you have the disease if you test POSITIVE

Smaller: LESS chance you have the disease if you test NEGATIVE

90
Q

How do you calculate the chances of the disease after the test?

A

Chance of disease before x Likelihood ratio

91
Q

Define screening

A

Systemic application of a test to identify individuals at sufficient risk of disorders to warrant further investigation / preventative action in individuals who have not sought medical attention on account of symptoms of that disorder

92
Q

When is screening used?

A

When more definite tests are more dangerous

93
Q

What type of prevention is screening?

A

Secondary

94
Q

What are the 4 things you need to appraise when looking into a screening tecnhique

A
  1. Condition
  2. Test
  3. Treatment
  4. Programme
95
Q

5 factors about the condition

A

Important health problem (difficult)
Understanding of history and epidemiology
Detectable risk factor
Latent period
Cost effective primary intervention in place

96
Q

4 (5) factors about the test

A

Simple, safe, precise, validated and acceptable
Known distribution of test values
Suitable cut-off agreed
Agreed policy on further management

97
Q

4 factors about the treatment

A

Effective treatment
Evidence that early treatment = better outcome
Agreed policy on who is offered treatment
Current clinical management is effective

98
Q

5 factors about the programme

A

RCT evidence that the programme will reduce morbidity and mortality
Evidence that it is acceptable
Benefit outweighs harm
Opportunity cost balanced
Plan for quality assurance and continuation of programme

99
Q

Explain over-diagnosis

A

Most cancers are slow growing and would never have caused medical problems but people now have to live with the consequences of the treatment

100
Q

Define length bias

What is the problem with this?

A

Screening detects slow progressing tumours

Individuals detected through screening have an automatically better prognosis

101
Q

Define selection bias

A

People who opt into screening are more health aware

102
Q

Define lead time bias

2 ways to overcome this

A

Screening makes the disease live longer not the person

Survival needs to be significant
Measure deaths prevented not survival

103
Q

What is good about good screening?

A

Early detection decreases cancer mortality

104
Q

What is bad about good screening?

A

Some people have no benefit

Some people get the disease despite a negative screening result

Medicine - Year 2 (19 decks)

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