HDL, LDL, TAG Flashcards
TAG
triaglycerol
VLDL
very low-density lipoproteinn
what happens with increased circulating TAG
increases TAG transported as VLDL
unloading of TAGrich VLDL
unload onto HDL and LDL
what happens to tag rich HDL
catabolised in kidney so fewer HDL
what happens in tag rich LDL
tag gets hydrolysed, leading to smaller, dense LDL
effect of TG rich VLDL on lipoprotein profiles
VLDL increase = cholersterol increase = increased cholesterol delivery to vessel walls
fewer HDL particles to reverse cholesterol transport
how does HDL effect LDL
has an antioxidant role on LDL, modified LDL are proinflammatory and initiate plaque
what molecules are atherogenic
small dense LDL particles
how does training affect lipoprotein lipase
increases its activity in skeletal muscle and adipose tissue
benefits of training
improved delivery of FFA to active muscles
improved clearance of circulating TG
CVD patients show lower tag clearance after a fatty meal
what happens to VLDL cholesterol
transferred to HDL when the tag is cleared from VLDL by lipoprotein lipase
how does an insulin resistance affect TG
decreased TG clearance and increased FFA release
what reduces CVD risk
low plasma TAG, total cholesterol and LDL-C levels
high HDL-C levels
what happens after a single bout of exercise
muscle LPL increases, aiding tag clearance
hepatic fat handling also changes
improved insulin sensitivity
increase in LCAT activity
fructose consumption
increased fructose consumption increases circulating TG in men
