HD5 Herpes Virus Flashcards
What is this:
Herpes Simplex Virus 2
you know herpes, but if recurrent probs this one
What is this:
Herpes Simplex Virus 1
you know herpes, if not recurrent probs this one
What is this:
Varicella Zoster Virus
this is the chicken pox virus, reactivation causes shingles
What is this:
Cytomegalovirus
usaully assymptomatic, can occasionally cause glandular fever in adolescents when contracted, greatest concern is congenital infection and solid organ donners.
What is this:
Epstein Barr Virus
- young children ( asymptomatic or sore throat) and adolescents (glandular fever/ infectious mononucleosis)
- the one that causes oral hairy leukoplakia (white patches that cannot be rubbed off, sign pt is immunocompromised)
What is this:
Human Herpes Virus 6
Roseola Infantum (rash illness in infants) Common in infants aged 2 and younger
What is this:
Human Herpes Virus 7
Roseola Infantum (rash illness in infants) Common in infants aged 2 and younger
What is this:
Human Herpes Virus 8 (associated with Kaposi’s sarcoma)
Kaposi’s sarcoma associated virus
a type of cancer that can form masses in the skin, lymph nodes, or other organs. The skin lesions are usually purple in color. They can occur singularly, in a limited area, or be widespread.
1) How long do cold sores last?
2) (typically where are the lesions, and where can they be rarely?)
3) what is the treatment for cold sores?
4) what are the triggers of cold sores?
1) 5-12 days
2) typically at vermillion border of lips, rarely intra-oral (but still can be)
3) 5% Aciclovir (most effective during active replicaiton, usually can feel tingling or itching before vesicles
4) many: including UV radiation, cold, menstruation, fever, stress
1) How long do cold sores last?
2) (typically where are the lesions, and where can they be rarely?)
3) what is the treatment for cold sores?
4) what are the triggers of cold sores?
1) 5-12 days
2) typically at vermillion border of lips, rarely intra-oral (but still can be)
3) 5% Aciclovir (most effective during active replicaiton, usually can feel tingling or itching before vesicles
4) many: including UV radiation, cold, menstruation, fever, stress
Which HSV 1 or 2, usually causes meningitis?
HSV2
what is meningitis known as if it is recurrent ?
mollaret’s meningitis
What are the main complications of HSV 1 or 2?
6
- secondary bacterial infections
- corneal ulcers
- meningitis
- herpes simplex encephalitis
- neonatal herpes simplex (life threatening (mother gives birth to baby before she has time to develop immunity)
- death (in immunocomprimised)
HSV in genitals, reactivation is usually HSV __a__.
the pimmary infection is b
a) 2
b) either
in genital HSV, what is worse primary or reactivation infection, which can be asymptomatic?
primmary is worse, secondary can be assymptomatic
What type of infections can HSV cause?
1) oral manifestation
2) genitals
3) hands = herpetic whitlow (most common amongest dentists, lesions on hands)
4) eyes= ocular infection
5) in babies= neonatal infections
6) brain =encephalitis
What does a HSV occular infection look like?
a little crack in the jelly of the eye
how does HSV infection affect delivery of babies?
if mother has active primary or initial genital HSV at time of delivery then will have a C section, unless recurrent as doesn’t out weigh the risks of the C sections
describe the mortality of HSV if untreated in babies?
high
what 3 parts of the body can neonatal HSV affect?
mucocutaneous only (mildest), primarily Central Nervous System or Disseminated.
What ways can a baby get HSV?
contact during delivery adn post-delivery
cold sores, asymptomatic shedding in close contacts
What is the most common virus cause of encephalitis?
2) neurological outcome?
HSV
2) poor (high rate of poor neurological outcome)
what is the mortality of untreated encephalitis?
2) what is the treatment?
70%
2) Mimimum of 10 days treatment with intravenous aciclovir is needed
(most would give 21 days).
What are the methods of detecting HSV?
Direct Viral Detection (PCR = polymerase chain reaction)
Lesion swab
Cerebrospinal fluid
