HASHIMOTO'S THYROIDITIS

Question 1

What are the exogenous causes of HT?

Answer 1

Infections,
Iodine
Imbalance
Vitamin D deficiency
Stress

Question 2

Under notable molecules of HT, what are the molecules that exposes CD4+ T helper cells to thyroid antigens?

Answer 2

Thyroglobulin
Thyroid Peroxidase

Question 3

What orgen do HT targets?

Answer 3

Thyroid gland

Question 4

These factors also promotes inflammation and contribute to destruction of the thyroid cells

Answer 4

Cytokines
TNF-alpha,
IFN-y and;
IL-1

Question 5

What are the GENERAL signs and symtoms of T1DM?

Answer 5

fatigue and weakness
weight gain
cold intolerance
constipation
muscle weakness
depression or mood
changes

Question 6

What are the SPECIFIC signs and symtoms of T1DM?

Answer 6

goiter
puffy face
bradycardia
hoarseness or voice changes
menstrual changes
dry skin
hair thinning or hair loss

Question 7

What are the notable Ab under HT?

Answer 7

Antibodies to thyroglobulin
Antibodies to thyroid peroxidase (TPO)
The third major autoantibody anti-TSHR antibody

Question 8

results in a characteristic
floccular or puffy staining
pattern

Answer 8

Indirect immunofluorescent assays

Question 9

most commonly used that
involves using tanned
RBCs

Answer 9

Passive hemagglutination

Question 10

measures the
concentration of TPOAbs
in serum

Answer 10

Chemiluminescent immunoassay

Question 11

patient’s serum is added to plate coated with TPO

Answer 11

Enzyme immunoassays (EIA)

Question 12

• measure how much iodine the thyroid absorbs

Answer 12

Radioactive Iodine Uptake Test

Question 13

• Bioassays
• Binding Assays

Answer 13

TSHR Antibodies Measurement