GRAVE'S DISEASE

Question 1

It is an autoimmune disorder that results from
an excessive output of thyroid hormones
caused by abnormal stimulation of the
thyroid gland by circulating
immunoglobulins

Answer 1

Grave’s disease

Question 2

A form of hyperthyroidism

Answer 2

GRAVES’ DISEASE

Question 3

What are the exogenous causes of Grave’s disease?

Answer 3

Cigarette Smoking
Excess Iodine
Pregnancy
Infections

Question 4

Under the NOTABLE MHC MOLECULES this is the most strongly associated MHC molecule with Grave’s disease.

Answer 4

HLA-DR3

Question 5

Under the NOTABLE MHC MOLECULES of GD this is a part of Graves’ disease genetic makeup

Answer 5

HLA-DQ2

Question 6

Under the NOTABLE MHC MOLECULES of GD this is along with HLA-DQ2, is commonly associated with celiac disease

Answer 6

HLA-DQ8

Question 7

What is the target organ of GD?

Answer 7

Thyroid gland

Question 8

What is the effect of GD in tissue?

Answer 8

Exopthalmos

Question 9

This refers to the bulging of the eyes that primarily affects retro-ocular tissues, including the extraocular muscle and connective tissue surrounding the eyes

Answer 9

Exopthalmos

Question 10

What characterizes the immune interaction of GD?

Answer 10

Thyroid-stimulating immunoglobulins

Question 11

Under the immune interaction of GD, where to the TSI bind to?

Answer 11

Thyroid stimulating hormone

Question 12

To what sex is GD more common?

Answer 12

Females

Question 13

GD occurs when?

Answer 13

Third or fourth decade of life

Question 14

What are the general symptoms of GD?

Answer 14

INCREASED METABOLISM
FATIGUE
HEAT INTOLERANCE
SLEEP DISORDERS
ANXIETY AND NERVOUSNESS
TREMORS
PALPITATIONS
COGNITIVE EFFECTS
GASTROINTESTINAL
SYMPTOMS
SEXUAL DYSFUNCTION

Question 15

What are the specific symptoms of GD?

Answer 15

GOITER
GRAVES’ OPTHALMOLOGY
SKIN CHANGES
MENSTRUA
CHANGES
MUSCLE WEAKNESS

Question 16

What are the notable Ab under GD?

Answer 16

Thyroid-stimulating antibodies / TSI
Thyroid Stimulating Hormone Receptor Antibodies