Hard drug mechanisms

Question 1

Agomelatine

Answer 1

Melatonin receptor 5-HT2 blocker

Seasonal depression

Question 2

Tianeptine

Answer 2

AMPA modulator, modulation of stress induced glutaminergic transmission, atypical mu agonist
Alcohol withdrawal depression

Question 3

Bupropion

Answer 3

DAT and NET inhibitor

Stuporus depression and quitting smoking

Question 4

Trazodone

Answer 4

Antagonist 5-HT2, partial agonist 5-HT1 and antagonist for alpha receptors.
Sleeping pill and atypical antidepressant, anxiolytic

Question 5

Buspirone

Answer 5

5-HT1 agonist.

anxiolytic

Question 6

Mirtazepine

Answer 6

5-HT2 and 3 blocker.

Depression

Question 7

Cariprazine

Answer 7

D3 and 2 partial agonist.

Bipolar + antipsychotic

Question 8

Aripiprazole

Answer 8

D2 partial agonist, 5-HT2 antagonist.

Question 9

Tiapride

Answer 9

Selective D2/3 antagonist.

Question 10

Risperidone

Answer 10

Mixed D2 and 5-HT2 antagonist + NE. Fewer SE and less EPS.

Question 11

Clozapine & olanzapine& quetiapine (tricyclic)

Answer 11

Mixed D2 and 5-HT2 antagonist

Question 12

Valproate

Answer 12

Na+ channel blocker, T-type calcium channel and GABA modulator.

Question 13

Phenytoin

Answer 13

Na+ channel blocker.

Question 14

Carbamazepine

Answer 14

Na+ channel blocker.

Question 15

Lamotrigine

Answer 15

Na+ channel blocker and decrease glutamate release.

Question 16

Ethosuximide

Answer 16

T-type calcium channel blocker. 2nd line abscence.

Question 17

Levetiracetam

Answer 17

Modulate GABA glutamate release.

Question 18

Vigabatrin

Answer 18

Block GABA transaminase.