Hallmarks of Cancer

Question 1

List 5 hallmarks of cancer

Answer 1

• Evading growth suppressors
• Avoiding immune destruction
• Enabling replicative immortality
• Tumour promoting inflammation
• Activating invasion & metastasis

Question 2

List 5 more hallmarks of cancer

Answer 2

• Inducing angiogenesis
• Genome instability & mutation
• Resisting cell death
• Deregulating cellular energetics
• Sustaining proliferative signalling

Question 3

Inhibitors targeting the signalling pathways of evading growth suppressors

Answer 3

Cyclin dependent kinase inhibitors

Question 4

Inhibitors targeting the signalling pathways of avoiding immune detection

Answer 4

Immune activating anti CTLA4 mAb

Question 5

Inhibitors targeting the signalling pathways of enabling replicative immortality

Answer 5

Telomerase inhibitors

Question 6

Inhibitors targeting the signalling pathways of tumour promoting inflammation

Answer 6

Selective anti inflammatory drugs

Question 7

Inhibitors targeting the signalling pathways of activating invasaion and metastasis

Answer 7

Inhibitors of HGF/c-Met

Question 8

Inhibitors targeting the signalling pathways of inducing angiogenesis

Answer 8

Inhibitors of VEGF signalling

Question 9

Inhibitors targeting the signalling pathways of genome instability and mutation

Answer 9

PARP inhibitors

Question 10

Inhibitors targeting the signalling pathways of resisting cell death

Answer 10

Proapoptotic BH3 mimetics

Question 11

Inhibitors targeting the signalling pathways of deregulating cellular energetics

Answer 11

Aerobic glycolysis inhibitors

Question 12

Inhibitors targeting the signalling pathways of sustaining proliferative signaling

Answer 12

EGFR inhibitors