Hall 8 - Acute Radiation Syndrome

Question 1

What happens after the prodromal syndrome?

Answer 1

Latent period (no symptoms) lasting hours to weeks

Then progress to cerebrovascular, GI, or hematopoietic syndrome

If no latent period, then initial dose was very high

Question 2

What total body dose causes the hematopoietic syndrome?

Answer 2

2.5-10 Gy

Question 3

What total body dose causes the gastrointestinal syndrome?

Answer 3

10-50 Gy

Question 4

What total body dose causes the cerebrovascular syndrome?

Answer 4

> 50 Gy

Question 5

When does death occur with the hematopoietic syndrome?

Answer 5

30-60 days
(after mature circulating cells are depleted)

Question 6

When does death occur with the gastrointestinal syndrome?

Answer 6

3-10 days
(compromised mucosal barrier, loss of gut crypt stem cells)

Question 7

When does death occur with the cerebrovascular syndrome?

Answer 7

24-48 hours

Question 8

What is the LD 50/60 with and without medical intervention?

Answer 8

= lethal dose to 50% of patients after 60 days

7 Gy with intervention
3.5 Gy without