Hall 19 - Dose-Response Relationships for Model Normal Tissues

Question 1

What kind of dose response curve is seen for both tumor control and normal tissue damage?

Answer 1

Sigmoid (deterministic)

Question 2

What is the therapeutic index?

Answer 2

Ratio of tumor control to normal tissue damage

Question 3

After radiation, how do most cells die? What is the exception?

Answer 3

Mitotic death
Lymphocytes die mainly from apoptosis

Question 4

What is a senescent cell?

Answer 4

Alive and metabolically active but unable to divide
(“dead” by clonogenic assay)

Question 5

What do clonogenic assays do?

Answer 5

Test for reproductive integrity (cell division) of irradiated cells

Question 6

What cells are most sensitive to radiation?

Answer 6

LEAST to MOST:
1. Thyroid
2. Testis stem cells
3. Jejunal crypt cells
4. Mammary cells
5. Bone marrow colony forming units
6. Human ataxia telangiectasia cells