Hall 4 - Radiosensitivity & Cell Age in Mitosis Flashcards
1
Q
What is the most variable phase in the cell cycle in mammals?
A
G1
2
Q
What cell cycle synchronization technique is used to shake cells off the monolayer during mitosis?
A
Mitotic shake-off
Harvest and replate cells in sync
3
Q
How is hydroxyurea used for cell cycle synchronization?
A
Kills cells in S
Arrests cells at G1 to S transition
4
Q
What is the most radioresistant phase in the cell cycle?
A
Late S phase
5
Q
What is the most radiosensitive phase in the cell cycle?
A
M
(G2 is similar)
6
Q
Does the oxygen enhancement ratio vary throughout the cell cycle?
A
No
7
Q
What is the most radiosensitive phase in the cell cycle for high LET radiation?
A
Little variation at very high LET
