haemostasis and thrombosis Flashcards
anticoagulant pathways: recall the function and importance of anticoagulant pathways
features of regulation at rest
collagen and tissue factors are separated from vWF and platelets; endothelial proteins are anti-thrombotic e.g. heparin and nitrix oxide
what does antithrombin do
present in blood and binds to thrombin, neutralising it; acts as a direct inhibitor of other proteinases e.g. FXIa, FIXa, FXa
what does heparin do
makes antithrombin more reactive
how is protein C activated
when endoehtlial thrombomodulin binds to thrombin, it changes activity from fibrinogen cleaving to activating protein C
what do protein C-cofactor protein S complexes do
down-regulate thrombin production via degradation of FVa and FVIIIa
what does thrombomodulin do
catched thrombin if it tries to move from clot, preventing spreading
what is the process of clot breakdown called
fibrinolysis
process of fibrinolysis
tissue plasminogen activator and plasminogen bind to fibrin, allowing cleaving to plasmin → plasmin cleaves fibrin to produce fibrin degradation products → antiplasmin stops plasmin from moving to rest of circulatory system, preventing all systemic fibrin being degraded
