Haemostasis and thrombosis

Question 1

What is the most abundant receptor on platelets?

Answer 1

GPIIb/IIIa, GP1b

Question 2

What is Bernard Soulier?

Answer 2

A serious inherited platelet disorder

Results from a lack of GPIb, meaning VWF cannot bind

Question 3

What is Glanzmann’s?

Answer 3

A serious inherited platelet disorder

Results from a lack of GPIIb/IIIa, meaning there is no ability for fibrinogen to clot

Question 4

What are the different types of Von Willebrand disease?

Answer 4

Type 1: mild-moderate
Protein works but it is deficient

Type 2: Protein is slightly deficient and defective

Type 3: complete absence of protein

Question 5

How is Von Willebrand disease treated?

Answer 5

DDAVP (desmopressin)

- stimulates the release of VWF from endothelial cells

Question 6

What does antithrombin inhibit?

Answer 6

Thrombin, Xa, VII, IX, XI

Question 7

Which member is antithrombin a member of?

Answer 7

Serine Protease Inhibitor family

Question 8

Is the activity of antithrombin increased or decreased by the presence of heparin?

Answer 8

Increased 5-10,000 fold in the presence of heparin

Physiologically binds to heparin sulphate on the surface of the vascular endothelium

Question 9

What are Protein C+S? What do they do?

Answer 9

They are vitamin K dependent glycoproteins synthesised in th eliver
Protein C = serine protease that inactivates Va and VIIa
Protein S = cofactor for activated Protein C