COPD Flashcards

1
Q

What is COPD?

A

Chronic obstructive airway disease

- incompletely reversible poor airflow + inability to breathe OUT fully

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2
Q

Give 2 examples of COPD. Why are they classified as COPD?

A

Emphysema
Chronic bronchitis
- poor airflow due to breakdown of lung tissue
- small airway disease
- results in poor absorption and release of respiratory gases

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3
Q

When is there the greatest reduction of airflow in COPD and why?

A

Breathing out/exhalation

The pressure in the chest compresses the airways

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4
Q

What are the risk factors for COPD?

A
  1. Smoking (BIGGEST risk factor)
    - -> women more susceptible to harmful effects than men
  2. Air pollution
  3. Occupational exposure
  4. Genetics (⍺-1-antitrypsin deficiency)

other risk factors may include:

  • asthma + airway hyperactivity
  • LBW
  • HIV/AIDS and TB
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5
Q

When should COPD be suspected?

A

In anyone over the age of 35-40 who has:

  • SOB
  • chronic cough
  • sputum production
  • frequent winter colds
  • history of exposure to risk factors
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6
Q

How is COPD diagnosed?

A
  1. Spirometry:
    - FEV1:FVC is < normal range (~0.75-0.8)
  2. Decrease in DLCO/TLCO (due to decreased surface area int he alveoli, as well as capillary bed)

*in the elderly spirometry would over-diagnose COPD
therefore, COPD symptoms, low FEV1:FVC and an FEV! < 80% of predicted is required for diagnosis

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7
Q

Why can smoking lead to COPD?

A
  • Smoking inactivates the elastase inhibitor ⍺-1-antitrypsin
  • there is release of serine elastase
  • elastic tissue of lung is destroyed
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8
Q

Describe the different GOLD grades for severity of COPD.

A
  1. Mild/GOLD1 = ≥ 80% of predicted FEV1
  2. Moderate/GOLD2 = 50-79%
  3. Severe/GOLD3 = 30-49%
  4. Very severe/GOLD4 = <30%
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9
Q

Describe the MRC shortness of breath scale in determining the severity of COPD.

A
  1. grade 1 = only on strenuous activity
  2. grade 2 = vigorous walking
  3. grade 3 = with normal walking
  4. grade 4 = after a few minutes of walking
  5. grade 5 = with changing clothes
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10
Q

What would a CXR of a COPD patient show?

A
  • overexpanded lungs
  • flattened diaphragm (most reliable sign)
  • increased retrosternal airspace
  • bullae
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11
Q

What is the differential diagnoses for COPD?

A
  1. congestive heart failure
  2. pulmonary embolism
  3. pneumonia
  4. pneumothorax
  5. bronchopulmonary dysplasia
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12
Q

What are the goals of treatment for COPD?

A
  1. reduce risk factors
  2. manage stable COPD
  3. prevent and treat acute exacerbations
  4. manage associated illnesses
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13
Q

Which vaccines must a person with COPD have and how often?

A
  • influenza vaccine once a year

- pneumococcal vaccine every 5 years

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14
Q

What are the treatment options for a COPD patient?

A
  1. smoking cessation (reduce mortality)
  2. O2 supplementation (reduce mortality)
  3. exercise (pulmonary rehabilitation, ideal BMI)
  4. bronchodilators
  5. corticosteroids
  6. long-term antibiotics (to reduce frequency of exacerbations)
  7. surgery (transplant, or volume-reduction)
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15
Q

When should O2 supplementation be given to a COPD patient?

A

When their ppO2 is <50-55mmHg or SaO2 <88%

**do not let SaO2 rise above 92%

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16
Q

What kinds of bronchodilators are given? (give examples)

A

Major types are: 𝛃2 agonists and anticholinergics (long and short-term)

  • reduce SOB, wheeze, exercise limitation, improve QOL
  • long-acting partly work by reducing hyperinflation

Short-acting 𝛃2 agonists = salbutamol, terbutaline
Long-acting 𝛃2 agonists = formoterol, salmeterol, indacterol

*the anticholinergics used in COPD are antimuscarinics = ipratropium (short-acting) and tiotropium (long-acting)

17
Q

What is the MOA of antimuscarinics (anticholinergics)?

A
  • blocks muscarinic receptors (some block M3 - tiotropium -, some are non-specific - ipratropium)
  • this promoted the degradation of cyclic guanosine monophosphate (cGMP)
  • decreased intracellular cGMP
  • reduces intracellular cGMP
  • reduces intracellular Ca2+
  • prevents contraction if smooth muscle = bronchodilator etc
18
Q

What can trigger COPD exacerbations?

A
  1. environmental pollutants (poor air quality)
  2. infections
  3. personal smoke and second-hand smoke
  4. cold temperature

*bear in mind that pulmonary embolism can worsen the S+S of COPD

19
Q

How would a person with an acute exacerbation of COPD present?

A
  • SOB
  • increased sputum production
  • change in colour of sputum (clear –> green/yellow)
  • increase in cough
  • tachypnoea
  • tachycardia
  • sweating
  • active use of accessory muscles
  • cyanosis
  • confusion
  • crackles on auscultation
20
Q

What happens/changes occur in a COPD patient when there is increased airway inflammation?

A
  • increased hyperinflation
  • reduced expiratory flow
  • worsening of gas transfer
  • can lead to insufficient ventilation = low SaO2
  • result in narrowing of arteries of the lungs + breakdown of capillaries (emphysema)
  • increased BP in pulmonary arteries

**can lead to cor pulmonale

21
Q

What is cor pulmonale?

A

abnormal enlargement of the right side of the heart

- can be caused by increased BP in pulmonary arteries as a result of COPD exacerbation

22
Q

How should a COPD exacerbation be treated/managed?

A
  • usually by increasing the use of SABA
  • can also combine with short-acting anticholinergics
  • in this case you SHOULD give O2 as SaO2 is <88%
  • continue to monitor pulse oximetry and ABGs
  • corticosteroids could improve recovery and reduce duration of symptoms