Haemostasis

Question 1

Name 4 things which activate platelets.

Which 2 of these are released by platelets.

Answer 1

Extravascular collagen surfaces
Thomboxanes A2
Thrombin
ADP

Thromboxanes A2 and ADP

Question 2

What factors require vitamin K?

Answer 2

2 7 9 10

Question 3

What pro and anti coagulative substances are secreted by the endothelium?

Answer 3

Pro
- vWF and TF

Anti

• Thrombomodulin
• tPA

Question 4

Name 4 substances which oppose clotting.

Answer 4

Protein C and S
FDPs
Antithombin

Question 5

What factors does the APTT measure activity of?

Answer 5

Intrinsic pathway

8 9 11 12

Question 6

What factors does PT measure?

Answer 6

Extrinsic pathway

7

Question 7

What are the 2 functions of vWF?

Answer 7

Assists in platelet plug formation by attracting platelets to site of vessel damage
Stabilises factor VIII

Question 8

What is one of the main symptoms of vW disease.

Answer 8

Mucosal bleeding.

Question 9

What are 2 causes of decreased platelets survival?

Answer 9

Immune thrombocytopenic purpura

DIC

Question 10

Give some causes of DIC

Answer 10

Sepsis
Severe trauma (brain)
Large burns
COmplciations of childbirth