Cellular Adaptation Flashcards
1
Q
What are the 3 roles of p53?
A
Cell cycle arrest
Apoptosis
Initiate DNA repair
2
Q
What is the role of pRb?
How do cyclin-CDK complexes affect this role?
A
Prevent progression from G1 to S.
They phosphorylate pRb - inactivating it allowing for progression into the next step of the cell cycle (S).
3
Q
What is barret’s oesophagus?
What is the cause?
A
Stratified squamous to gastric/ intestinal epithelium due to oesophageal reflux
Lower oesophageal sphincter damage