Cellular Adaptation Flashcards

1
Q

What are the 3 roles of p53?

A

Cell cycle arrest
Apoptosis
Initiate DNA repair

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2
Q

What is the role of pRb?

How do cyclin-CDK complexes affect this role?

A

Prevent progression from G1 to S.

They phosphorylate pRb - inactivating it allowing for progression into the next step of the cell cycle (S).

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3
Q

What is barret’s oesophagus?

What is the cause?

A

Stratified squamous to gastric/ intestinal epithelium due to oesophageal reflux

Lower oesophageal sphincter damage

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