Haemostasis Flashcards
1
Q
Platelets role in haemostasis
A
- Adhere
- Activation
- Aggregation
- Provide phospholipid surface for coagulation
2
Q
What does thrombin do to fibrinogen
A
Turns it into Fibrin
3
Q
What forms the primary haemostatic plug when a vessel tears
A
-Platelets
4
Q
What forms the clot that goes over the primary haemostatic plug
A
Fibrin
5
Q
Describe plasminogen’s role in fibrin clots
A
- t-PA + u-PA convert it to Plasmin
- Plasmin then dissolves the fibrin clot
6
Q
How does warfarin work
A
- Inhibits Vit K synthesis
- Which inhibits clotting factors II, VII, IX and X
- ?prevents prothrombin being cleaved to form thrombin?
- ?No thrombin to convert fibrinogen to fibrin?
7
Q
How does heparin work
A
- Activates antithrombin III (AT)
- AT then inactivates thrombin + factor Xa
- Thrombin then can’t convert fibrinogen to fibrin
8
Q
How does Rivaroxaban work
A
- Inhibits factor Xa
- Which inhibits thrombin formation (?prevents prothrombin becoming thrombin?)
9
Q
What is responsible for the local development of an appropriate clot
A
- Platlets
- Von Willebrand Factor
- Coagulation factors
10
Q
What is the local development of a clot limited by
A
-Natural anticoagulants
11
Q
How are appropriate clots cleared up
A
The fibrinolytic system
