Haemostasis Flashcards
What are the roles of platelets in haemostasis?
Adhere
Activation
Aggregation
Provide phospholipid surface for coagulation
What happens when a vessel becomes damaged?
Platelets adhere to damaged area Primary haemostatic platelet plug forms Fibrin formation Clot forms Clot confined to area of tissue damage Clot lysis and tissue repair
What are some clotting agents?
Factor XII Factor XI Factor IX Factor VIII Factor X Prothrombin Fibrinogen
What clotting factor is absent in haemophilia A?
Factor IX
What clotting factor is absent in haemophilia B?
Factor VIII
What is the pathway of fibrin formation?
Prothrombin is converted into thrombin
Thrombin allows fibrinogen to be converted into fibrin
What are the natural anticoagulants?
Activated Protein C
Protein S
TFPI
Antithrombin
What part of the coagulation pathway does warfarin inhibit?
Factor IX, X, VII
Prothrombin
What part of the coagulation pathway does heparin inhibit?
Factor Xa
Thrombin
What part of the coagulation pathway does rivoroxaban, edoxaban and apixaban inhibit?
Factor Xa
What part of the coagulation pathway does dabigatran, bivalirudin and argatroban inhibit?
Thrombin
Where does clopidogrel, prasugrel and ticagrelor act on?
ADP
Where does Aspirin act on?
Inhibits aracadonic acid converting to thromboxane A2
Where does Abciximab, Tirofiban and Eptifibatide act on?
GP IIb/ IIIa
What is the act of removing a clot naturally?
Fibrinolysis
