Autoimmunity

Question 1

What is the treatment of autoimmune disease?

Answer 1

Immunosuppressive therapy
Anti-inflammatory therapy
Plasmapheresis
Stem Cell/Bone Marrow Transplant
Replacement of lost physiological factor
Organ / tissue / mechanical graft

Question 2

What are the immune features of multiple sclerosis?

Answer 2

T cells specific to myelin cross the BB and release cytokines
BBB damage, macrophage and Tc cell migration attacks oligodendrocytes

Question 3

What are sentinel cells?

Answer 3

Cells in the body’s first line of defence which embed themselves in tissues

Question 4

What is autoimmunity?

Answer 4

Physiological autorecognition with secondary epiphenomena

Question 5

What causes autoimmunity?

Answer 5

Genetic factors
Hormonal factors
Environmental factors
Immune regulation

Question 6

What is cell mediated immunity?

Answer 6

T and NK cells interact with cells bearing the antigen they don’t recognise
Stop cells that could potentially lyse and release viruses

Question 7

What is antibody mediated immunity?

Answer 7

Antibody binds to targets leading to damage by Fc receptor macrophage with or without complement lysis
Type 2 hypersensitivity reaction

Question 8

What is immune complex autoimmunity?

Answer 8

Antigen-antibody/Immune complex formation and deposition, activating phagocytes and causing damage
Type III Hypersensitivity reaction