Haemopoiesis Flashcards

1
Q

What are the 3 steps of Haemopoiesis? and what happens?

A

TOO MUCH PDA

  1. Proliferation (multiplication)
  2. Differentiation (change shape)
  3. Apoptosis (cell death)
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2
Q

What regulates haemopoiesis?

A

Growth factors

  1. Colony stimulating
  2. Interleukins
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3
Q

What do growth factors stop?

A

they stop apoptosis.

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4
Q

Where are these growth factors made?

A

Glycoproteins

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5
Q

Where are glycoproteins produced?

A
  1. Stromal cells
  2. T lymphocytes
  3. Liver
  4. Kidney
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6
Q

Where are haemopoietic stem cells from?

A

Originally formed in the mesoderm (then stored in marrow)

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7
Q

Why are haemopoietic stem cells rare? (and give 4 facts)

A
  • 1:20 million ratio of stem cell vs normal cell
  • their phenotype is unknown (CD34+, CD 38-, negative linage)
  • able to self renew
  • look like small lymphocytes
  • can always find its way back to the bone marrow
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