Erythropoiesis

Question 1

What is erythropoiesis?

Answer 1

Red blood cell production

Question 2

What hormone regulates erythropoiesis?

Answer 2

Erythropoietin

Question 3

Where is erythropoietin produced?

Answer 3

Kidney

Question 4

What is the earliest erythroid precurser?

Answer 4

BM-Pronormoblast (a.k. Proerythroblast)

Question 5

What happens to a RBC’s normoblast in each cell division?

Answer 5

gets smaller (early, intermediate and late)

Question 6

Why doesn’t a RBC have a nucleus?

Answer 6

a erythrocyte has no nucleus and it is pushed out. however before it full matures (as a reticulocyte- it contains ribosomal RNA)

Question 7

Explain the steps of ejecting a nucleus of a RBC, that allow a erythroblast to become a reticulocyte and then finally an erythrocyte.

Answer 7

Phase 1- Ribosome synthesis
Phase 2- Haemoglobin accumulation
Phase 3- Ejection of Nucleus
Erythroblast–>Reticulocyte–> Erythrocyte.

Question 8

stages of RBC development

Answer 8

1. Normoblast
2. Reticulocyte
3. Erythrocyte