Granulopoiesis, Monocytopoiesis and Lymphopoiesis

Question 1

What do granulocytes and monocytes have in common? and what are they both regulated by?

Answer 1

both produced from a common myeloid precursor cell

both regulated by growth factors (colony stimulating and interleukin)

Question 2

Which specific CSF and Interleukins regulate granulopoiesis and monopoiesis?

Answer 2

• IL3: neutrophils, basophil and monocytes.
• IL5- eosinophils
• GM-CSF (granulocyte-macrophage CSF)

Question 3

Steps in the formation of a granulocyte (Granulopoiesis)

Answer 3

1. Myeloblast
2. Promyelocyte
3. Myelocyte
4. Metamyelocyte
5. Band Formation
6. Neutro/Euosino/Basophil formed

Question 4

Steps monocytopoiesis.

Answer 4

1. Monoblast
2. Promonocyte
3. Marrow monocyte
4. Blood monocyte
5. Tissue macrophage

Question 5

4 facts about monocytes

Answer 5

1. 20-40 hours in circulation
2. Variable morphology
3. 1 nucleus and grey cytoplasm
4. Phagocytoses and destroys bacteria

Question 6

What is lymphopoiesis regulated by?

Answer 6

IL1, 2, 4, 6 and 7

Question 7

Steps in Lymphopoiesis.

Answer 7

1. Lymphoblast
2. Prolymphocyte
3. Large Lymphocyte
4. Small Lymphocyte

Question 8

What are the 2 types of lymphocytes?

Answer 8

1. B Lymphocytes

2. T Lymphocytes

Question 9

What do lymphoid stem cells produce?

Answer 9

B and T cell lymphocyte progenitors

Question 10

Where do B lymphocyte cells mature and where do they then go to?

Answer 10

B cells mature in the marrow. They then move from the blood to peripheral lymphoid tissues (lymph nodes and spleen)

Question 11

Where are T lymphocyte cells produced?

Answer 11

T cells are produced in the marrow.

Question 12

Where do T lymphocyte cells mature and where do they then go to?

Answer 12

T Cells mature in the thymus. They then move to peripheral lymphoid organs.

Question 13

What are the 4 roles of B Lymphocytes?

Answer 13

• Responsible for humoral immunity
• Secrete surface receptors/ antibodies against foreign antigens
• They cause cell proliferation into plasma cells
• Produce rapid response to further contact with inducing antigen

Question 14

What are the 2 roles of T Lymphocytes?

Answer 14

• Responsible for cellular immunity

- The specific antigen must be present on the macrophage for T cells to be activated

Question 15

What are the 5 types of T Lymphocytes?

Answer 15

1. T helper
2. T memory
3. T regulator
4. T cytotoxic
5. NK