Haemopoiesi

Question 1

types of MPV

Answer 1

essential thrombocytheameia ^ palateles
plycythenthaemia vera ^ RBC
myelofibrosis harden ofboen amr
chronic myeloid leukaemia over proditionf of myeloid family

Question 2

clinicalfactures

Answer 2

hyperceullaur marrow f/ibrosis marrow
^^ genetic disorders d ^^ prilfieration
exrameduallro erthpoeies

Question 3

polycythemia vera

Answer 3

- high haemotcrit ^ RBC
JAK6 V417F gene defect
no cause give the diagnosis 
^ pagltelate adnd neutrophils
affects males and females 
60 year old diagnosis

Question 4

complication

Answer 4

^thrmobosis so c arterial thromoboiss
venous thrombosis
haemorrhage into skin dn GI
pretties d b in perihery thicker spedallya fret showering b of vasdilation
splenic discomfort
gout 
c become MPD or laukima

Question 5

treatment for poly

Answer 5

take RBC out a drainage
use aspiring as antipaltflt to v risk of thrmobis
manage CVS risk factors
some drugs

Question 6

polyc

Answer 6

RELATIVE- less fluid c v plasma so ^ haemotocrit sopolycthemia
-durectics same as above
PRIAMRY = pcv
SECODNARY
-d increased erythropoietin and this can be pshyicaloogy aporoaite d hypoxia or physiclalogicacl inapportiate

Question 7

secondary causes of poly

Answer 7

• hypoxia d altitude / lung diseases like COPD / renal kidney d renal artsy stenosis and plycystisc disease c local hypoxia
• atholgicalu ; heptacellualr carcinoma dn renal cell cancer uterine cancer phaeochromocytomaall produce EPO
• drugs in doping

Question 8

mcv image

Answer 8

image

Question 9

thrmobocytheame a

Answer 9

too muchplatalet d large and excess megakaryocytes in bone marrow

Question 10

treatment for thr

Answer 10

thmrootqic

• asporin
• hydroxycarbomide with high risk patients

Question 11

^ platelet tsts

Answer 11

- infection
inflammation
tissue surgery
haemoeggahe 
cancer
psot spleciony or hypospelenticy 
make sure repeated b test tho

Question 12

myelofibrosis

Answer 12

huge spleen but patient okay c of extramedulalry haemotopoeis
cortex ossified so little space of
tear drop cell so get deformed as they squeez eout and become tear drop

Question 13

clinical presnt of myelo

Answer 13

large spleen infants , splenic, cant eat much=early satiety

Question 14

cml

Answer 14

high WCC
- v rare in kids disease of adults
lots of WBC and myelocyes in the blood wc should be in the bm
hyeprovisocty and pain of spleen pus like blood

Question 15

c of cml

Answer 15

switch of material from chrome 9 and 22 c philadeldephia chromosome

Question 16

pantcytopenia

Answer 16

reduction all WB RBc and platelets

Question 17

c>

Answer 17

reduced production or increased removal via spleen polling or immune destruction
haemophagostysis

Question 18

reduced vit b an d folate

Answer 18

vit b12/folate deficieny
virus like HIV,EBV (c glandular fever), CMV
-bone marrow infiltration by cancer
-marrwo fibrosis
-radiation of bone marrow
-idiopathic aplasia anaemia
-congenital bone marrow failure  
-liver failure since it make TPO

Question 19

aplastic anaemia

Answer 19

pancytopmeia w hypocelullat bone marrow of abnormal infiltrate with no increase fibrous
- d immune

Question 20

platelet

Answer 20

c b formation by forming platelet plug

• adhesion to damaged endothelial wall
• actvaite change ins Hape from disc to release granules
• agregare aún clump together

Question 21

disorder of platelets

Answer 21

• thrmococythemia
  -normal number but
  -aquired; decreased platelet produce
  -increased playlet consumption ; massive haemraghe
  increaedjkjfdgjksb,sbgj

Question 22

symtoms of thr

Answer 22

dotty rash = petechia purpura
look into mouth msucoal bleeding common
bleeds of retina b looking at eye
<30
intracranial haemoorage

Question 23

immune palatal destrucion

Answer 23

most common c antibodies against glycoporin GP immune destruction of thrombosis
kids d infection and can leave
adults comes randomly
treatment ; suppress immersions system , nose bleedsblsites in mouth, platelet transfusion don’t work as they are destroyed too

Question 24

dieseas

Answer 24

hereditary; Bernard souilerssyndrome, glanzmann’s thrmbasthenia
acquired ; apsprin/NASIDS/ clopiderols inhibit normal platelet function
uraemia