Adrenal Disorders Flashcards
adrenal gland parts and their function
outer = cortex (most outer layer to inner)
- zona glomerulosa ; mineralocorticoids (aldosterone) NA+ and K+ levels
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zona fasciculata ; glucocorticoids ( cortsiol and corticosterone metabolism of carbohydrates
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zona reticularis ; androgens sex hormone
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zona reticularis ; androgens sex hormone
inner = medulla
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adrenaline
- noradrenaline
disorders of the adrenal cortex
too much hormones of the adrenal corex or too little
- adrenal insufficiency
- congenital adrenal hyperplasia
- hyperaldosteronism
disorders of the adrenal medulla
pheochromocytoma and paraganglioma
clinical presentation of adrenal hormone deficiency
-autoimmune infiltration of immune cells -addisons disease ; v in
what hormones are decreased in adrenal deficiency
cortisol , androgens , mineralocorticoid
why is androgen deficiency worse in women
because its the only source of androgen
cortisol def.
- tired, lethargy , low blood sugar since its anti -insulin -treatment is tablets
aldosterone def.
- dizziness, since lose water, too much potassium
androgen def.
- loss of hair and axillae, and v libido
too much cortisol
- cushings syndrome
too much aldosterone
- high blood pressure and low potassium
excess ACTH
- d low cortisol
adrenal medulla dsiease
palpitations,, ^/vbp, anzixety
assessment for adrenal cortex diseases
- blood tests basal cortisol test 0900 - stimulation test ; give ACTH
stimulation test vs supressio test
- give ACTH
supress
- electrolytes -cortisol midnight - 24hours urine cortisol
how to test the adrenal medulla
- 24 urine catechol - 24 urine metanephrines (break down components of ad/nad) - plasma metanephrine (more sensitive than urine) - tell patients to not have coffee, chocolate, vanilla
imaging of adrenal diseases
-CT -MRI -functional imaging -PET -MBG
Addisons disease
-primary adrenal failure -skin pigmentation., vitiligo, pig. accentuation of the nipples , freckling , darkening of hair, underweight , thyroid problems , low bp when stand up, nausea -c autoimmune isolated or polyglandular, -infection (TB< FUNGAL< AIDS -infiltration , amyloid, -malignancy lung, breast, -T = lifelong meds of gluocortisol , mineralocorticoid
adrenal crisis
- § ; collapse, hypotension, dehydration, pigmentation, coma - treatment is rehydration and cortisol