Haemophilis and Bordetella

Question 1

Both haemophilus and bordetella are

Answer 1

human restricted, fastidious in culture, and require factors X and V in vitro

Question 2

Both transmitted by

Answer 2

respiratory droplets, mostly-pediatric contagious respiratory infection, vaccines available, treat with antibiotics and supportive care

Question 3

Haemophilus are

Answer 3

gram neg, pleomorphic: could appear as cocci, rods, mixture on microscopy!!

Question 4

Encapsulated H influenzae (Hib) are more

Answer 4

pathogenic, covered by vaccination, cause lethal meningitis;
bacteremia quickly follows UR infection and underlies all invasive disease: meningitis, cellulitis, epiglottitis, septic arthritis

The MEN CELL SEPtres

Question 5

Unencapsulated H influenze (NTHi):

Answer 5

less pathogenic but nOT covered by vaccination. May be normal flora; lack capsule but STILL have IgA protease, pili, adhesins like Hib. Cause neonatal and postpartum sepsis, CF pneumonia, systemic complications after untreated local mucosal infections, particularly with respiratory or immune predisposition.

SPiCe

Question 6

B pertussis is a

Answer 6

highly contagious short Gram neg rod; incidence and mortality increasing b/c of inadequate vaccine coverage. Acellular vaccine used in US has shorter-lived protection than killed-cell, used abroad

Question 7

Pertussis:

Answer 7

filamentous hemagglutinin attaches, pertussis toxin exotoxin causes ciliary stasis leading to cough for contagion. NO BACTEREMIA, and good prognosis

Question 8

Whooping cough is

Answer 8

prolonged (about 3 mo) even with drug treatment, dangerous with underlying conditions, leukocytosis on bloodwork