Enteric 1 and 2 Flashcards
Picornaviruses, noroviruses, and rotaviruses are all
small, nake, icosahedral RNA viruses. Enteroviruses are the subset of picornavirses that cause GI infection
Rotavirus has a
segmented genome, causes potentially-dangerous dehydrating diarrhea
Norovirus is extremely
contagious, low infectious dose, short hard bout of vomiting and diarrhea
Enteroviruses do their main replication in
the gut, but also cause viremia with replication in regional lymp nodes and can rarely penetrate the CNS, thus infection is usually mild but occasionally devastating
Noroviruses, rotaviruses, and enteroviruses are all
widespread worldwide, though the course of the disease in the first world is substantially attenuated by hygiene and vaccination
REN are environmentally
rugged, allowing for fecal-oral transmission
REN can cause
self-limited GI illness, usually resolving without medical intervention or complication. Most common complications are dehydration w/ roto (watch for pediatric anorexia and lethargy), CNS infection with enteroviruses
Most of the problematic enteric virus infections are
pediatric; the younger, the WORSE. Coxsackie B is 10% lethal in neonates
Coxsackie A symptoms (_____________) are usually
herpangina, AHC, HFMD;
less severe than Coxsackie B (myocarditis, pleurodynia, meningitis), but there is overlap
HFM:
vesicles on those three plus inside the diaper. Herpangina: ulcerating vesicles inside mouth. Pleurodynia: severe intermittent chest pain with pleural fiction rub
What can be used to isolate the virus/and or detect its RNA?
Use LP, nasopharyngeal swabs, and/or stool culture; some serologic tests are available
Watch literature for
new approvals/contraindications for Pleconaril; all other care is supportive: rehydrate, rest, treat complications
