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blood science > haemoglobinpathies and haemostasis W6 and 7 > Flashcards

haemoglobinpathies and haemostasis W6 and 7 Flashcards

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Biology 101 flashcards
1
Q

what is haemoglobinopathies

A

synthesis of abnormal haemoglobin

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2
Q

what is a normal adult haemoglobin level

A

95-98%

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3
Q

structure of haemoglobin?

A

hb = 4 globin + haem

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4
Q

structure of haemoglobin?

A

hb = 4 globin + haem - contains Fe

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5
Q

what is thalassemia

A

reduced synthesis of haemoglobin

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6
Q

what is alpha thalassemia

A

deficiency in production of alpha haemoglobin chains due to a gene deletion in alphaglobin gene

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7
Q

what is beta thalassemia

A

deficiency in production of beta haemoglobin chains due to a point mutation in betaglobin

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8
Q

what are both alpha and beta thalaseemia

A

autosomal recessive

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9
Q

what does HPLC detect

A

different haemoglobin

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10
Q

what is primary haemostasis

A

vasoconstriction and platelet plug formation

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11
Q

what is secondary haemostasis

A

plates plug reinforced by conversion of fibrinogen to fibrin, coagulation cascade

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12
Q

what is the role of the von willebrand factor

A

platelets agglutinate to damages vascular sub-endothelium

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13
Q

what are factors affecting haemostasis

A

anticoagulants

liver disease

vitamin K deficiency

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14
Q

what are factors affecting haemostasis

A

anticoagulants

liver disease

vitamin K deficiency

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15
Q

what are natural coagulants

A

proteins C, S

antithrombin

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16
Q

what are hereditary diseases that lead to abnormal bleeding

A

Haemophilia A and B

17
Q

what is disseminated intravascular coagulation (DIC)

A
  • fibrin generated
  • pro-coagulant clotting factors and platelets are used for no reason
18
Q

what is the treatment for DIC

A

blood transfusions

cryoprecipitate

heparin used to control thrombosis

19
Q

why are RH antibodies important

A

used to detect compatibility if two blood groups are mixed

20
Q

what is given to women to prevent haemolytic disease in children

A

K-

blood science (8 decks)

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