Haemoglobin Flashcards
What state is the iron molecule in a Haem molecule?
the iron molecule is in the Fe2+ state
What ion in the haem group attaches to an oxygen molecule?
Fe2+ attaches to the oxygen molecule
How many bonds does Fe2+ make with Haem?
Fe2+ makes 6 bonds with haem
How many Hb molecules are there per Erythrocyte?
640 million Hb molecules per erythrocyte
What percentage of an erythrocyte’s content is Hb?
Hb is 95% of a erythrocyte’s content
What are the 2 types of chains found in HbA haemoglobin
the chains found are alpha and beta
How many O2 molecules can a Haem group carry?
1 haem group can carry 1 O2 molecule
What is the structure of Haemoglobin?
Haemoglobin is a atom of ferrous (Fe2+) surrounded by a porphyrin ring
What are the types of bonds and number of these type of bonds that Fe2+ makes with the rest of the Haem molecule?
Fe2+ makes:
- 4 bonds to nitrogen atoms
-1 bond to the Oxygen atom
- 1 bond to histidine residue on the alpha chain
What does histidine residue from the alpha chain do?
Histidine residue prevents oxidation of the iron from Fe2+ to Fe3+
What does cooperative binding do?
Cooperative binding increases the affinity for the binding of the next oxygen molecule
When is a haemoglobin molecule fully saturated?
It is fully saturated when 4 Oxygen molecules are bound
what is the complex known as when oxygen and haemoglobin are bound together?
the complex is known as oxyhaemoglobin
what is the complex known as when haemoglobin is carrying less oxygen than usual?
the complex is known as deoxyhaemoglobin
What is the complex called when haemoglobin is bound with CO2?
the complex is known as carbaminohaemoglobin
