Haematopoiesis Flashcards
hey
What is the largest component of the blood
Plasma
What is Haematopoiesis
process by which blood cells are formed
life span of erythrocytes
120 days
life span of platelets
9-10 days
Where does Haematopoiesis take place in an adult
vertebrae, ribs, sternum,skull,sacrum,pelvis and proximal end of femur
In an infant where does Haematopoiesis take place in an infant
bone marrow
What is red marrow made of
haematopoietic tissue
What is yellow bone marrow made of
Fat cells
microenvironment of stroll cells and matrix
What is the CFU-GEMM also called
myeloid stem cell
What is the order of making a mature erythrocyte
Myeloid stem cell Proerythroblast Erythroblasts Normoblasts reticulocyte Mature erythrocyte (RNA lost)
What is the growth factor for red blood cells
Erythropoietin
What is thrombopoiesis
production of platelets
What stimulates the production of platelets
Thrombopoietin
What is the process of production of megakaryoblasts
endomitosis
What is the largest WBC
Monocyte
What is the most abundant WBC
neutrophile
What do Eosinophils protect against
parasites
do all WBC have nucleus
yes bro
where does GATA-1 differentiates cells
erythropoietic and megakaryocytic cell lineages
where does PU.1 differentiate cells
myeloid lineage
Erythropoietin (EPO)
Regulates erythropoiesis
Mainly synthesised in kidneys and liver
Reduction in red cell number results in decreased oxygen to tissues
Development of hypoxia in kidneys and liver
Leads to increased production of red blood cells
This corrects hypoxia and EPO synthesis switched off
what does IL-3 help with
Works in conjunction with GM-CSF to proliferate most haemopoietic progenitor cells
what does IL-5 help with
Plays a role in growth and differentiation of eosinophils
where it Il-5 produced
T lymphocytes
