Haematopoiesis Flashcards
What is haematopoiesis?
Production of red blood cells, white blood cells and platelets
Where does haematopoiesis occur?
Bone marrow
Which bones are active in haematopoiesis in children?
Most of the bones of the skeleton
Which bones are active in haematopoiesis in an adult?
Axial skeleton
- skull
- sternum
- ribs
- vertebrae
- pelvis
When might a bone marrow biopsy/aspirate be taken?
Abnormal blood cell count
Where is a bone marrow biopsy/aspirate taken from?
Iliac crest
How do you look at the samples from a bone marrow biopsy/aspirate?
Under a microscope
What is the difference between a bone marrow biopsy and aspirate?
Biopsy - sample taken includes bone and bone marrow
Aspirate - sample taken includes bone marrow only
When would you choose a bone marrow aspirate over a biopsy?
When want to look at specific type of blood cells
How is haematopoiesis controlled?
Hormones
What stimulates erythropoiesis?
Erythropoietin
What stimulates thrombopoiesis?
Thrombopoetin
What stimulates granulocyte development?
G-CSF
granulocyte-colony stimulating factor
What stimulates lymphocyte development?
Interleukins
Tumour necrosis factors
