haematopoiesis Flashcards
site of haematopoiesis at birth
- bone marrow
- liver
- spleen
site of haematopoiesis from birth to maturity
- number of active sites in BM decreases but retain ability
Site of haematopoiesis in adults
-skull
- ribs
-sternum
-pelvis
-proximal end of femur (the axial skeleton)
which cells are produced more frequently in the haematopoietic cycle?
- erythrocytes
- platelets
- granulocytes
explain maturation of neutrophils (granulopoiesis)
- myeloblast
- promyelocyte
-myelocyte - metamyelocyte
- neutrophils (as seen in blood)
Explain maturation of neutrophils (granulopoiesis)
- myeloblast
- promyelocyte
- myelocyte
- metamyelocyte
- neutrophils (as seen in blood)
explain maturation of erythrocyte (erythropoiesis)
- pronormoblast
- basophilic/ early normoblast
- polychromatophilic/ intermediate normoblast
- orthochromatic/ late normoblast
- reticulocyte
- mature red cell/ erythrocyte
what are the different types of white cells?
granulocytes
- eosinophils
- basophils
- neutrophils
structure of neutrophil
- segmented nucleus (polymorph)
- neutral staining granules
Structure and function of eosinophil
- usually bi-lobed
- bright orange/red granules
-fight parasitic infection
- hypersensitivity
- commonly elevated in patients with allergic conditions (asthma, atopic rhinitis)
Structure and function of Basophils
- infrequent in circulation
- large deep purple granules (weird nucleus)
-granules contain histamine
- circulating version of tissue mast cell
- binds IgE?
what shares a common precursor with granulocyte?
Monocytes
Structure and function of monocytes
- large single nuclei
- faintly staining
- live longer than neutrophils
- circulate for a week and then enter tissue to become macrophage
- present antigen to lymphocytes
Structure of lymphocytes
- small condensed nucleus and rim of cytoplasm
- when activated (known as atypical and they suggest infection like EBV)
has blue cytoplasm with more open nucleus
what is the common site for BM aspiration and biopsy?
Posterior iliac crest
