Haematology_Neutrophils Flashcards
What are the cause of transient neutropenia
Viral (Repeat in 1/52)
Drugs
Causes of chronic neutropenia
Dec production, inc destruction, sequestration (neutrophils sitting in spleen), dilution issue
Neonatal alloimmune neutropenia autoimmune neutropenia of infancy Bengin granulocytopenia Hypersplenism Congenital Neutropenia
What are causes of congenital neutropenia?
Kostmann syndrome (mutation of ELA2)
- Neutropenia <0.2
- Recurrent infections
- Treatment requires GCF / BM transplant
Shwachman syndrome
Autoimmune neutropenia of infancy:
- Pathophysiology
- Require Abx for fever?
1.Increase destruction secondary to autoimmune autoantibodies
Spontaneous resolution and remission by 4 yrs of age
2.Not for triple Abx with fever
What lab level concern regarding severe neutropenia, when is it suitable for referral?
<1.0x10^9/L
Causes of neutrophillia
Bacterial/Fungal/Viral/TB Blood loss DKA burns Steroids
When should eosinophilia be referred?
> 3.0x10^9/L
Causes of Lymphopenia
Post viral
Steroids
Unless baby with lymphopenia - may have immune deficiency
Causes of atypical = reactive lymphocytes
adults = EBV
paediatric - viral
Children with EBV (unlikely to c/o sore throat)
- Is the mono spot useful
- Investigations
- discharge advice
Note: EBV will get better with 10/7
- Not for <4yr olds
- IgM (increases quickly, IgG then)
- Will get better in 10/7
Thrombocytopenia
with high MCV should alert
Further investigation with BM aspirate for ?leukemia
increase or decrease WCC with increase MCV should prompt
Further investigation with BM aspirate for ?leukemia
