Haematology & Oncology

Question 1

What is the most common extracranial solid childhood malignancy?

Answer 1

Neuroblastoma

Neuroblastic tumours = arise from primitive cells of sympathetic system

Vast majority arise from the ADRENAL GLAND
Third most common childhood tumour after leukaemia and brain malignancy

2/3 intraabodominal, 1/3 intrathoracic

Question 2

What are the accompanying syndromes of neuroblastoma?

Answer 2

1. Hutchinson syndrome
2. Pepper syndrome
3. Blueberry muffin syndrome
4. Opsomyoclonus

Question 3

What are the XR findings of neuroblastoma?

Answer 3

Non-specific mass, 30% have calcifications

Question 4

What other diseases is neuroblastoma associated with?

Answer 4

NF1, DiGeorge, BWS, Hirschsprung