Haematology Formative 24/01/20

Question 1

What is the characteristic genetic abnormality in Chronic Myeloid Leukaemia?

1. t(15;17) ATRA gene
2. t(9;22) Philadelphia chromosome
3. t(8;21) AML/ETO gene
4. t(8;14) cMYC oncogene

Answer 1

2. t(9;22) Philadelphia chromosome

Question 2

What class of drug best describes Rituximab?

1. Cytotoxic chemotherapy
2. Disease-modifying therapy
3. Monoclonal antibody
4. Antibiotic

Answer 2

3. Monoclonal antibody

Question 3

Which age group is characteristically affected by Hodgkin lymphoma?

1. Children
2. Teenagers and young adults
3. Middle aged (40-60 yrs)
4. Older aged (>60yrs)

Answer 3

2. Teenagers and young adults

Question 4

How is myeloma bone disease usually assessed?

1. Plain X-ray
2. Clinical assessment
3. Isotope bone scan
4. PET scan

Answer 4

1. Plain X-ray

Question 5

What is the correct mechanism of action for the anti-emetic drug Ondansetron?

1. Peripheral D2 antagonist
2. Central D2 antagonist
3. Anti-cholinergic
4. 5HT3 antagonist

Answer 5

4. 5HT3 antagonist

Question 6

What is the commonest cause of microcytic anaemia?

1. B12 deficiency
2. Iron deficiency
3. Haematologic malignancy
4. Hereditary spherocytosis

Answer 6

2. Iron deficiency

Question 7

In sickle cell anaemia what would you expect to see the reticulocyte count?

1. Absent
2. Low
3. Normal
4. Raised

Answer 7

4. Raised

Question 8

Bacterial infection usually causes:

1. Low lymphocytes
2. Low neutrophils
3. High lymphocytes
4. High neutrophils

Answer 8

4. High neutrophil count

Question 9

Which best outlines the approach to the management of a patient with suspected febrile neutropaenia?

1. Encourage fluids and paracetamol
2. Perform cultures and wait for results before starting antibiotics
3. Perform cultures and start oral antibiotics
4. Perform cultures and start broad spectrum iv antibiotics

Answer 9

4. Perform cultures and start broad spectrum iv antibiotics

Question 10

Malignant spinal cord compression usually presents with?

1. Back pain, ataxia and sensory neuropathy
2. Back pain, spastic paresis and a sensory level
3. Perianal numbness and urinary incontinence
4. Weak legs impaired joint position sense

Answer 10

2. Back pain, spastic paresis and a sensory level

Question 11

How does Aspirin exert its antiplatelet effect?

1. ADP receptor antagonist
2. Inhibition of Cyclooxygenase enzyme
3. Inhibition of Glycoprotein IIb-IIIa
4. Inhibition of PAR4 receptor

Answer 11

2. Inhibition of Cyclooxygenase enzyme