Haematology Flashcards
1
Q
what is pernicious anaemia?
A
autoimmune
plasma & lymphoid cell infiltration causes atrophic gastritis
loss of parietal cells: intrinsic factor production failure, vitamin B12 malabsorption, achlorhydria
2
Q
what is achlorhydria?
A
absence of HCl in gastric secretions
3
Q
causes of microcytic anaemia?
A
iron deficiency
chronic disease
thalassaemia
sideroblastic anaemia
4
Q
causes of iron deficiency
A
blood loss
increased demand [growth, pregnancy]
decreased absorption [small bowel disease]
poor intake
5
Q
management of iron deficiency anaemia
A
find and treat underlying cause
oral iron
[parenteral iron, rarely necessary]
6
Q
anaemia of chronic disease occurs in patients with …?
A
inflammatory: Crohn’s disease, RA
infection: TB
malignancy
CKD
