GU Flashcards

1
Q

which hormone causes enlargement of the prostate from boy > man?

A

dihydrotestosterone

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2
Q

is cancer, or benign prostate enlargement more likely to push on the urethra?

A

benign
[benign - transitional zone
cancer - outer zone]

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3
Q

what is PSA?

A

prostate specific antigen
non-specific blood test for prostate cancer
[liquefaction of semen, small leakage into blood]

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4
Q

2 most common areas of mets in prostate cancer

A

lymph nodes

bone

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5
Q

what are paraneoplastic sydromes?

A

rare
triggered by altered immune response to neoplasm
non-mets systemic effects w/ malignant neoplasm

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6
Q

non-spec systemic symptoms of cancer

A

weight loss
fever
normocytic anaemia

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7
Q

specific constitutional symptoms in cancer caused by hypercalcaemia

A

anorexia
thirst
confusion
collapse

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8
Q

why does cancer cause hypercalcaemia?

A

bone breakdown
dehydration (vomiting) > kidney fn. impaired
parathyroid hormone related protein secreted by tumour > bone resorption & tubules

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9
Q

specific constitutional symptoms in cancer caused by marrow replacement

A

purpura
anaemia
immune suppression

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10
Q

examples of paraneoplastic syndromes

A
cushing's disease
dementia
cerebellar degeneration
peripheral neuropathy
acanthosis nigricans
erythrocytosis
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11
Q

what type of cancer is prostate?

A

adenocarcinoma

[prostate GLAND]

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12
Q

Which zone of the prostate is affected by adenocarcinoma?

A

peripheral zone

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13
Q

5 cancers that tend to metastasise to bone

A
breast
lung
prostate
thyroid 
kidney
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14
Q

what is an androgen?

A

male sex hormone e.g. testosterone

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15
Q

prostate cancer genetics - oncogene that links with TMPRSS2 gene, leading to disruption of androgen receptor signalling

A

ERG

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16
Q

reasons for elevated PSA other than prostate cancer

A

benign prostate enlargement
UTI
prostatitis
recent ejaculation

17
Q

how does prostate cancer grading [Gleason] differ from norm?

A

looks a TISSUE not cell

grading not related to cellular differentiation. How close/far from normal tissue?

18
Q

describe T1 stage in prostate cancer

A

no palpable tumour on DRE

19
Q

describe T2 stage in prostate cancer

A

palpable tumour confined to prostate

20
Q

describe T3 stage in prostate cancer

A

palpable tumour extending beyond prostate

21
Q

treatment for localised prostate cancer

A

surgery
radiotherapy
observation

22
Q

arguments against radical prostatectomy

A

erectile & sexual dysfn.
urinary incontinence
most die WITH not OF it

23
Q

what is the purpose of the wider diameter of the afferent arteriole than the efferent in the kidney?

A

increases blood pressure within glomerulus

forces water and solutes into bowman’s capsule

24
Q

most common disease of kidney/urinary tract in men?

A

benign prostatic hypertrophy

25
Q

most common disease of kidney/urinary tract in women?

A

UTI

26
Q

what is dysuria?

A

pain on micturition

27
Q

structural and functional abnormalities in which glomerular cell leads to nephrotic syndrome?

A

podocytes

28
Q

management of nephrotic syndrome

A

oedema: dietary salt restriction, thiazide diuretic
proteinuria: ACE inhibitors, angio2 rec. blockers
severe: cyclophosphamide/prednisolone
[treat underlying disease]

29
Q

how do ACE inhibitors/ angiotensin2 receptor blockers decrease proteinuria?

A

decrease BP in glomerulus so less forced filtration

30
Q

complications of nephrotic syndrome

A

venous thrombosis
sepsis
AKI

31
Q

how can nephrotic syndrome lead to sepsis?

A

loss of immunoglobulin in urine

^ infections

32
Q

how can nephrotic syndrome lead to venous thrombosis?

A

loss of clotting factors in urine

33
Q

what causes acute nephritic syndrome/ acute glomerulonephritis?

A

immune response triggered by infection e.g. post strep pharyngitis
bacterial antigen trapped in glomerulus

34
Q

clinical features of acute glomerulonephritis/ acute nephritic syndrome

A
haematuria
proteinuria
hypertension
oedema
oliguria
uraemia
35
Q

Tx of acute glomerulonephritis

A

HTN: salt restriction, loop diuretics, vasodilators
oedema: fluid restriction
if SLE/vasculitis: prednisolone, cyclophosphamide..