GU Flashcards
which hormone causes enlargement of the prostate from boy > man?
dihydrotestosterone
is cancer, or benign prostate enlargement more likely to push on the urethra?
benign
[benign - transitional zone
cancer - outer zone]
what is PSA?
prostate specific antigen
non-specific blood test for prostate cancer
[liquefaction of semen, small leakage into blood]
2 most common areas of mets in prostate cancer
lymph nodes
bone
what are paraneoplastic sydromes?
rare
triggered by altered immune response to neoplasm
non-mets systemic effects w/ malignant neoplasm
non-spec systemic symptoms of cancer
weight loss
fever
normocytic anaemia
specific constitutional symptoms in cancer caused by hypercalcaemia
anorexia
thirst
confusion
collapse
why does cancer cause hypercalcaemia?
bone breakdown
dehydration (vomiting) > kidney fn. impaired
parathyroid hormone related protein secreted by tumour > bone resorption & tubules
specific constitutional symptoms in cancer caused by marrow replacement
purpura
anaemia
immune suppression
examples of paraneoplastic syndromes
cushing's disease dementia cerebellar degeneration peripheral neuropathy acanthosis nigricans erythrocytosis
what type of cancer is prostate?
adenocarcinoma
[prostate GLAND]
Which zone of the prostate is affected by adenocarcinoma?
peripheral zone
5 cancers that tend to metastasise to bone
breast lung prostate thyroid kidney
what is an androgen?
male sex hormone e.g. testosterone
prostate cancer genetics - oncogene that links with TMPRSS2 gene, leading to disruption of androgen receptor signalling
ERG