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UWORLD Q BANK review > Haematology > Flashcards

Haematology Flashcards

1
Q

Which blood product causes transfusion transmitting bacterial infection?

A

Platelet transfusion

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2
Q

Neonate with unconjugated hyperbilirubinaemia on phototherapy, does not improve. What is the next step of management?

A

Do exchange transfusion and find pathological causes like RH incompatibility and G6PD deficiency

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3
Q

Middle-aged woman with generalised pruritus and tender hepatosplenomegaly. Elevated haemoglobin, haematocrit and leucocytes elevated liver enzymes. What is the best next step to evaluate this patient?

A

Abdominal Doppler ultrasonography for reduced hepatic vein flow, suspecting for myeloproliferative disorders. Next do JAK2 testing

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4
Q

Triad of Wiskott Aldrich syndrome. How do you treat?

A

Microthrombocytopenia, eczema, recurrent infections. Hematopoietic stem cell transplantation.

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5
Q

Drugs causing peripheral neuropathy

A

VIncristine, cisplatin, taxanes, phenytoin, isoniazid, amiodarone, hydralazine

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6
Q

SLE with B symptoms with generalised lymphadenopathy. Elevated LDH. Diagnosis? Confirmatory test?

A

Non Hodgkin lymphoma, excisional lymph-node biopsy

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7
Q

Which childhood lymphoproliferative disorder causes a bone pain?

A

ALL- neutropenia, thrombocytopenia, wbc- decreased or markedly increased

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8
Q

Young girl adopted from Nigeria presents with sudden onset weakness, hypotonia, hyper reflexia of right arm and leg, which additional test is done to diagnose after neuro imaging?

A

Haemoglobin electrophoresis. Confirm stroke with MRI

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9
Q

Von willebrand factor disease lab values.

A

All normal, elevated PTT

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10
Q

Work up in 60 yr males with firm fixed breast mass ?

A

Mammogram then core biopsy. Same as a female

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11
Q

60yr old female with blurred vision, headache, tingling, elevated protein, ESR. Dilated segmental tortuous retinal veins. No jaw tenderness, calcium normal? Next step?

A

Diagnosis- waldenstrom macroglobulinemia. Do serum protein electrophoresis

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12
Q

Massive transfusion protocols requirement. Blood products transfused?

A

More than 2 of the following-
1. Penetrating mechanism of injury.
2. Positive fast.
3. SBP less than 90.
4. Pulse more than 120
Blood products- 1:1:1- PRBC, FFP, platelets

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13
Q

Anaemia in diamond blackfan anaemia. Clinical findings and treatment.

A

Macrocytic, reticulopenia
CF- craniofacial abnormalities, triphalangeal thumbs, increase risk of malignancy
Rx- corticosteroids, RBC transfusions

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14
Q

Therapy given when standard treatment fails

A

Salvage therapy

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15
Q

Cells and associated diseases- target cells, bite cells, Heinz body, Howell jolly body, schistocyte, burr cell, spherocyte, basophilic stippling?

A

Target- thalassemia, bite Heinz - g6pd, Howell - asplenia, schistocyte- HUS, DIC, TTP, burr- EPO deficiency, spherocyte- AIHA, basophilic stippling- lead poisoning

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16
Q

Most common complication of sickle cell trait carrier

A

Hematuria

17
Q

Hereditary haemorrhagic telengiectasia

A

Osler Weber rendu syndrome- epistaxis, AV shunts, telengiectasias

18
Q

TTP Rx

A

Plasma exchange, high dose glucocorticoids, rituximab, caplacizumab

19
Q

4M bruising, gum oozing, buccal hematomas, b/l ant cervical LNpathy, hepatosplenomegaly

A

ALL- platelet deficiency

20
Q

15M CF- epistaxis

A

Vit K deficiency- absent coag factor act

21
Q

Dyspnea, fatigue, splenomegaly, hemolytic anemia labs+, PBS- spherocytes. Direct coombs test +

A

AIHA

22
Q

Haptoglobin levels in hemolysis

A

Decreased more in intravascular >extravascular

23
Q

Rx of AIHA

A

warm- corticosteroids, splenectomy
cold- avoid cold temp, rituximab +fludarabine

24
Q

3M fatigue, pallor, icterus, ecchymoses, thrombocytopenia, took med for diarr. PBS- shictocytes

A

HUS- MAHA

25
Q

Painless right neck lump, wgt loss, smokes, LN- firm, close to right submandibular. FNA- SCC. Source?

A

H&N carcinoma- laryngoscopy

26
Q

Hemolytic anemia labs+ dark urine, MRI- hepatic vein thrombosis

A

PNH- Rx- iron, folate supple, eculizumab

27
Q

ADR of hydroxyurea

A

myelosuppression

28
Q

Headache, confusion, icterus, anemia, thrombocytopenia. PBS- frag RBC. NBS

A

TTP- plasma exchange, glucocorticoids, rituximab, caplacizumab

29
Q

CF of TTP

A

fever, low platelets, AMS, renal insuff, MAHA

30
Q
A

UWORLD Q BANK review (17 decks)

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