Haematology Flashcards
What are Reed-Sternberg cells associated with?
Hodgkin’s Lymphoma
What changes would you notice to a blood test of a patient with Hereditary Spherocytosis?
Increased MCHC
Increased unconjugated bilirubin
Increased LDH
Decreased haptoglobin
Increased urinary urobilinogen
28F anaemic pregnant lady with dizziness and palpitations. Cause?
IDA
6monthF from Cypress with severe anaemia and failure to thrive, with frontal bossing. Cause?
Thalassaemia
25M night sweats and weight loss. Low-grade fever, systolic heart murmur and splenomegaly. Cause?
Infective Endocarditis
21M with sore throat, headache and generally unwell. Cervical lymphadenopathy and splenomegaly. Heterophile antibodies. Cause?
Infectious mononucleosis
Patients on warfarin with high INR. What action should you take?
INR 5-8
- No bleeding: Hold 1-2 doses then lower dose
- Minor bleeding: Stop warfarin, give IV vit K then restart then INR<5
INR >8
- No bleeding: Stop warfarin, give PO vit K and restart when INR <5
- Minor bleeding: Stop warfarin, give IV vit K then restart when INR <5
Major bleeding: Stop warfarin, give IV vit K and prothrombin complex
What abnormal cells are seen in AML?
Auer rods
What medication would you be on if pregnant with APS?
Aspirin and LMWH
60M with abdo pain, massive splenomegaly and WCC 90?
CML
Philidelphia chromosome present in >80%
70M with weight loss and painless cervical lymphadenopathy. Lymphocytes 15?
CLL
What are teardrop cells associated with?
Myelofibrosis
40F with painless cervical lymphadenopathy. Lymph node excision biopsy shows lymphoma but no Reed-Sternberg cells?
Non-Hodgkin Lymphoma
Treatment for polycythaemia vera?
If asymptomatic then venesection to keep the Hct below 50
If symptomatic (organomegaly and adverse symptoms) then immunosuppression
What is the treatment for primary thrombocytosis?
If asymptomatic then surveillance
If stroke/TIA/MI etc then aspirin and immunosuppression
