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Jack Teh Cheat Sheet Flashcards > Haem + Onco + Rheum/MSK > Flashcards

Haem + Onco + Rheum/MSK Flashcards

1
Q

Signs on blood film in G6PD?

A

Heinz bodies

Bite cells

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2
Q

Basophilic stippling- feature of what disease? [prob don’t need to know]

A

Lead poisoning, thalassaemia, sideroblastic anaemia, myelodysplasia

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3
Q

Blood film in multiple myeloma?

A

Rouleaux

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4
Q

When are reticulocytes elevated?

A

haemolytic anemia [both intravascular and extravascular]

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5
Q

Mediastinal mass and severe itching?

A

Hodgkin’s lymphoma

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6
Q

What is lymph node involvement like in Non hodgkin’s lymphoma?

A

Extranodal involvement common

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7
Q

Erythoderma?

A

T cell Non Hodgkins lymphoma

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8
Q

Features of myelofibrosis?

A

Hepatosplenomegaly
Dry tap biopsy- nothing comes out on biopsy
Fibrotic bone marrow
Hypercellular marrow- because linked to myeloproliferative disease
Blood film: tear drop cells/dacrocytes

Often asymptomatic
Linked with polycythemia rubra vera + JAK two

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9
Q

Sudan black stain
Down’s
Auer rods

A

AML

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10
Q

Which leukaemia does hyperuricaemia/gout happen in?

A

CML

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11
Q

Which leukaemias do you get high WCC [lymphocytes] in?

A

ALL, CLL, CML

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12
Q

What is platelet count like in Von willebrand disease?

A

Normal

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13
Q

ITP

A

Idiopathic bleeding of gums/nose + petechiae after viral infection [varicella zoster]= autoimmune

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14
Q

Tumour markers for testicular cancer?

A

bHCG- seminoma
aFP- teratoma
LDH

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15
Q

Cyclin D1-IGH / Bcl-6 gene translocation

TEL-JAK2 gene translocation

Bcl-2 gene translocation

C-myc gene translocation

A

Diffuse large B cell lymphoma

Myelofibrosis

Follicular lymphoma

Burkitt’s lymphoma

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16
Q

Lymphoma- what type?
Nasopharyngeal, throat pain, fatigue?

[African, EBV, NH lymphoma, starry sky?]

A

Burkitt’s lymphoma

17
Q

Lymphoma- what type?
Nasopharyngeal, throat pain, fatigue?

[African, EBV, NH lymphoma, starry sky?]

A

Burkitt’s lymphoma

18
Q

Risk factors for gastric squamous cell carcinoma?

A

Smoking
Alcohol

[Coeliac
Chinese
Male
Achalasia]

19
Q

What happens to calcium in tumour lysis syndrome?

A

Low

20
Q

Spinal cord compression - how does it affect the nerves?

A

Lower motor neuron signs AT lesion

Upper motor neuron signs BELOW lesion

21
Q

Side effects of doxorubicine [used for cancer]?

A

Arrthymia

Heart block

22
Q

SE: Severe haematuria + alkylating agent for myeloma

A

Cyclophosphamide

23
Q

SE: Peripheral neuropathy + microtubule inhibitor for Breast Ca

A

Paclitaxel(taxanes), vinblastine/vincristine (vinca alkaloids

24
Q

SE: Gynaecomastia + prostate cancer

A

Flutamide, cyproterone acetate (dihydrotestosteronereceptor blockers used to treat tumour flare associated with Tx with GHRH analogues e.g. gosereline

25
Q

SE: Gynaecomastia + prostate cancer

Other drugs causing gynaecomastia [from capsule]:

A

Flutamide, cyproterone acetate (dihydrotestosteronereceptor blockers used to treat tumour flare associated with Tx with GHRH analogues e.g. gosereline

	• Oestrogens and oestrogen agonists – digoxin, spironolactone
	• Hyperprolactinaemia – methyldopa, phenothiazines
	• Gonadotrophins
	• Testosterone target cell inhibitors – cimetidine, cyproterone acetate
	• Proton pump inhibitors
	• Finasteride
	• Anabolic steroids
	• Marijuana Heroin
26
Q

Mx of gout?

A

NSAIDS, colchicine, steroids

Long term: allopurinol

27
Q

Risk factors for pseudogout?

A

Hypovolaemia
hyperparathyroidism
hypoPO4

diabetes
hypoT4
acromegaly
haemochromatosis

28
Q

Multiple myeloma?

A

Constant backache + ESR+ Calcium Raised

29
Q

Scheuermann’s disease (abnormal ossification of ring epiphyses of thoracic vertebrae)

A

Young girl, backache, fatigue, worry she is becoming round-shouldered O/E: Smooth thoracic kyphosis, x-ray: Wedge-shaped verterbral bodies in thoracic spine

30
Q

Takayasu’s arteritis

A

Affects Asian women 20-40 years
Pulseless disease
FLAWS + weak/absent UL/LL pulse
Claudication

31
Q

Kawasaki disease

A

Under 5 years, protracted fever, acute cervical lymphadenopathy, bilateral non-purulent conjunctivitis, dry, cracked, fissured lips, redness, oedema of palms and soles

32
Q

Polyarteritis nodosa is associated with what infection?

A

Hepatitis B

33
Q

Antibody for polymyositis?

A

Anti-Jo 1

34
Q

What msk condition has raised CK?

A

Polymyositis

35
Q

Sjogren’s syndrome antibodies

A

Anti Ro and anti La

36
Q

Polymyositis investigations?

A

Muscle biopsy: inflammation, necrosis)

Jack Teh Cheat Sheet Flashcards (13 decks)

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