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AKT > Haem/ Onc > Flashcards

Haem/ Onc Flashcards

1
Q

Bleomycin SE

A

Lung fibrosis

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1
Q

Doxorubicin (Anthracycline) SE

A

Cardiomyopathy

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2
Q

Vincristine SE

A

Peripheral neuropathy

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3
Q

Docetaxel SE

A

Neutropenia

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4
Q

Antiphospholipid in pregnancy Mx

A

LMWH (Dalteparin) + Aspirin

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5
Q

Wells score 2 or more Mx

A

DVT Likely
- USS <4hrs
- If >4hrs for interim anticoagulation
- if +ve, for anticoagulation
- if -ve, for D Dimer
- if D Dimer +ve - repeat USS in 1 week

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6
Q

Wells score 1 or less

A

DVT Unlikely
-D Dimer <4hrs
- if >4hrs for interim anticoagulation
- if +ve, for USS <4hrs (if >4hrs for anticoag)

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7
Q

Spinal cord compression earliest and most common sign

A

back pain

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8
Q

G6PD deficiency contraindications

A

Sulpha drugs - Sulphonamides, Sulfasalazine, Sulfonylureas
Primaquine (antimalrial)
Ciprofloxacin
- trigger haemolysis

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9
Q

Sickle cell vaccinations

A

pneumococcal every 5 years

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10
Q

CA 15-3 association

A

breast ca

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11
Q

Cyclophosphamide SE

A

Haemorrhagic cystitis

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12
Q

Sickle cell crisis - Thrombotic crisis Fx

A

“painful or vaso occlusive” crisis
precipitated by infection, dehydration, deoxygenation (eg high altitude)
- Pain

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13
Q

Sickle cell crisis - Aplastic crisis Fx

A

caused by parovirus
sudden fall in Hb
LOW reticulocyte

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14
Q

Sickle cell crisis - Sequestration crisis Fx

A

anaemia and RAISED reticulocyte
pooling of blood in organs - splenomegaly

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15
Q

Drug induced pancytopenia causes

A

cytotoxics
antibiotics: trimethoprim, chloramphenicol
anti-rheumatoid: gold, penicillamine
carbimazole*
anti-epileptics: carbamazepine
sulphonylureas: tolbutamide

16
Q

VTE increased risk drugs

A

COCP
HRT - combined > oestrogen only
Raloxifen/ Tamoxifen
Antipsychotics eg olanzepine

17
Q

Most common thrombophillia

A

Factor V leiden

18
Q

Lymphoma Fx

A

Unresolving unexplained lymph nodes
itchiness

fever, night sweats, shortness of breath, pruritus and weight loss.

19
Q

Elderly person with lymphocytosis

A

Chronic Lymphocytic leukaemia

20
Q

haemophilia A lacks what clotting factor

A

Factor VIII
prolonged APTT

21
Q

Haemophilia B (Christmas disease) lacks what clotting factor

A

Factor IX
prolonged APTT

22
Q

Post splenectomy prophylactic abx

A

Phenoxymethylpenicillin (for 2 years)

23
Q

Polycythaemia ruba vera Fx

A

Bleeding, bruising
low grade fever, tired, night sweats, weight loss
Pruritis (esp in warm bath)

24
Q

ORBIT criteria

A

Older
Reduced Hb
Bleeding Hx
Insufficient kidney function
Treatment with antiplatelet

AKT (21 decks)

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