Haem/ Onc

Question 1

Bleomycin SE

Answer 1

Lung fibrosis

Question 1

Doxorubicin (Anthracycline) SE

Answer 1

Cardiomyopathy

Question 2

Vincristine SE

Answer 2

Peripheral neuropathy

Question 3

Docetaxel SE

Answer 3

Neutropenia

Question 4

Antiphospholipid in pregnancy Mx

Answer 4

LMWH (Dalteparin) + Aspirin

Question 5

Wells score 2 or more Mx

Answer 5

DVT Likely
- USS <4hrs
- If >4hrs for interim anticoagulation
- if +ve, for anticoagulation
- if -ve, for D Dimer
- if D Dimer +ve - repeat USS in 1 week

Question 6

Wells score 1 or less

Answer 6

DVT Unlikely
-D Dimer <4hrs
- if >4hrs for interim anticoagulation
- if +ve, for USS <4hrs (if >4hrs for anticoag)

Question 7

Spinal cord compression earliest and most common sign

Answer 7

back pain

Question 8

G6PD deficiency contraindications

Answer 8

Sulpha drugs - Sulphonamides, Sulfasalazine, Sulfonylureas
Primaquine (antimalrial)
Ciprofloxacin
- trigger haemolysis

Question 9

Sickle cell vaccinations

Answer 9

pneumococcal every 5 years

Question 10

CA 15-3 association

Answer 10

breast ca

Question 11

Cyclophosphamide SE

Answer 11

Haemorrhagic cystitis

Question 12

Sickle cell crisis - Thrombotic crisis Fx

Answer 12

“painful or vaso occlusive” crisis
precipitated by infection, dehydration, deoxygenation (eg high altitude)
- Pain

Question 13

Sickle cell crisis - Aplastic crisis Fx

Answer 13

caused by parovirus
sudden fall in Hb
LOW reticulocyte

Question 14

Sickle cell crisis - Sequestration crisis Fx

Answer 14

anaemia and RAISED reticulocyte
pooling of blood in organs - splenomegaly

Question 15

Drug induced pancytopenia causes

Answer 15

cytotoxics
antibiotics: trimethoprim, chloramphenicol
anti-rheumatoid: gold, penicillamine
carbimazole*
anti-epileptics: carbamazepine
sulphonylureas: tolbutamide

Question 16

VTE increased risk drugs

Answer 16

COCP
HRT - combined > oestrogen only
Raloxifen/ Tamoxifen
Antipsychotics eg olanzepine

Question 17

Most common thrombophillia

Answer 17

Factor V leiden

Question 18

Lymphoma Fx

Answer 18

Unresolving unexplained lymph nodes
itchiness

fever, night sweats, shortness of breath, pruritus and weight loss.

Question 19

Elderly person with lymphocytosis

Answer 19

Chronic Lymphocytic leukaemia

Question 20

haemophilia A lacks what clotting factor

Answer 20

Factor VIII
prolonged APTT

Question 21

Haemophilia B (Christmas disease) lacks what clotting factor

Answer 21

Factor IX
prolonged APTT

Question 22

Post splenectomy prophylactic abx

Answer 22

Phenoxymethylpenicillin (for 2 years)

Question 23

Polycythaemia ruba vera Fx

Answer 23

Bleeding, bruising
low grade fever, tired, night sweats, weight loss
Pruritis (esp in warm bath)

Question 24

ORBIT criteria

Answer 24

Older
Reduced Hb
Bleeding Hx
Insufficient kidney function
Treatment with antiplatelet