Haem

Question 1

pepper pot skull/lytic lesions

Answer 1

myeloma

Question 2

rouleaux formation

Answer 2

myeloma

Question 3

congo red staining

Answer 3

amyloid deposition of biopsied tissue in myeloma and AA amyloidosis

Question 4

Reed-Sternberg cells

Answer 4

Hogkin’s lymphoma

Question 5

philadelphia chromosome (9;22 translocation)

Answer 5

chronic myeloid leukaemia

Question 6

atypical lymphocytes

Answer 6

EBV (mononucleiosis)

Question 7

Auer rods

Answer 7

acute myeloid leukaemia

Question 8

Bence-Jones proteins

Answer 8

multiple myeloma

Question 9

itchy after a hot bath

Answer 9

polycythaemia rubra vera

Question 10

translocation (8;14)

Answer 10

burkitt’s lymphoma

Question 11

alcohol makes it worse

Answer 11

Hogkin’s lymphoma (probably also other things like fckn liver cirrhosis? but in haem context, Hodgkin’s I guess?)

Question 12

haemarthrosis

Answer 12

haemophilia

Question 13

reduced levels of factor IX w/ Christmas disease

Answer 13

haemophilia B

Question 14

young boy w/ reduced levels of factor VIII and an increased APTT

Answer 14

haemophilia A

Question 15

schillings test

Answer 15

B12 deficiency

Question 16

smudge cells (immature leukocytes)

Answer 16

chronic lymphoblastic leukaemia

Question 17

JAK-2 mutation

Answer 17

polycythaemia rubra vera or essential thrombocytopaenia

Question 18

NBT test

Answer 18

chronic granulomatous disease

Question 19

+ve Schumm’s test

Answer 19

intravascular haemolytic anaemia

Question 20

hair-on-end skull XR

Answer 20

major beta-thalassaemia

Question 21

bite cells, blister cells, and Heinz bodies

Answer 21

G6PD deficiency

Question 22

Russell bodies

Answer 22

chronic inflammation

Question 23

schistocytes

Answer 23

intravascular haemolysis

Question 24

myeloma (CRAB)

Answer 24

high Calcium, Renal insufficiency, Anaemia, Bone lesions